Evidence map›Paper›PMID 40579601›Full record

ReviewNature biotechnology2025

Improving engineered biological systems with electronics and microfluidics.

Rabia Tugce Yazicigil, Akshaya Bali, Dilara Caygara, Douglas Densmore

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rabia Tugce YazicigilElectrical and Computer Engineering Department, Boston University, Boston, MA, USA. rty@bu.edu.ORCID http://orcid.org/0000-0002-1492-2941
Akshaya BaliElectrical and Computer Engineering Department, Boston University, Boston, MA, USA.ORCID http://orcid.org/0009-0003-5640-1081
Dilara CaygaraElectrical and Computer Engineering Department, Boston University, Boston, MA, USA.ORCID http://orcid.org/0009-0002-1759-0193
Douglas DensmoreElectrical and Computer Engineering Department, Boston University, Boston, MA, USA. dougd@bu.edu.ORCID http://orcid.org/0000-0002-7666-6808

Funding

Catalyst Foundation 55208844National Science Foundation (NSF) 2338792
6 · The paper itself

Abstract

Hybrid engineered biological systems integrate electronics and microfluidics with engineered biological components, such as microbes or cell-free DNA-based systems, to effectively sense, act upon and report on biological environments. As these engineered biological systems become essential in addressing challenges in healthcare, environmental monitoring, remediation and agriculture, this Review offers an in-depth discussion of their applications, critical design choices and challenges. Alongside an overview of the state of the field, we present a classification framework aimed at helping researchers make informed and optimized design decisions tailored to the intended biological application. Furthermore, we outline how the development of cyber-secure biological systems could enhance the security and functionality of engineered biological platforms. Last, we introduce a 'Living Roadmap' ( https://www.programmingbiology.org/csbs ) to dynamically reflect the field's progress and support continuous monitoring of future advancements.

Indexed as

BioengineeringElectronicsMicrofluidicsHumansSynthetic Biology

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.