Evidence map›Paper›PMID 40579575›Full record

ArticleLung2025

Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study.

Howraman Meteran, Simon Francis Thomsen, Jacob Hjelmborg, Martin R Miller, Kaare Christensen, Torben Sigsgaard, Vibeke Backer

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Howraman MeteranDepartment of Respiratory Medicine, Copenhagen University Hospital - Hvidovre, Hvidovre, Denmark. hmeteran@gmail.com.
Simon Francis ThomsenDepartment of Dermatology, Venereology and Wound Healing Centre, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark.
Jacob HjelmborgDepartment of Epidemiology and Biostatistics, University of Southern Denmark, Odense, Denmark.
Martin R MillerInstitute of Occupational and Environmental Medicine, University of Birmingham, Birmingham, UK.
Kaare ChristensenDepartment of Epidemiology and Biostatistics, University of Southern Denmark, Odense, Denmark.
Torben SigsgaardDepartment of Public Health, Environment, Occupation and Health, Aarhus University, Aarhus C, Denmark.
Vibeke BackerDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmoking is a major risk factor for lung function decline and chronic obstructive pulmonary disease (COPD), but the individual susceptibility to these traits cannot be explained solely by environmental risk factors.

aimTo estimate the relative contribution of genetic and environmental factors to lung function, chronic bronchitis and COPD.

methods12,449 twins aged 40-80 years participated in a nationwide survey using the Danish Twin Registry, which included a questionnaire, clinical examination and spirometry. Clinical COPD was defined by respiratory symptoms plus airflow obstruction. Biometric models of genetic and environmental latent factors were used to estimate the heritability after adjusting for sex, age, and height.

resultsMean (SD) age of the study population was 58.4 (9.6) years and mean BMI (kg/m

conclusionGenetic factors explain at least half of the variation in lung function and around half of the individual susceptibility to chronic bronchitis and clinical COPD, respectively, when adjusted for sex, age, height.

Indexed as

Bronchitis, ChronicDiseases in TwinsGenetic Predisposition to DiseaseLungPulmonary Disease, Chronic ObstructiveAdultAgedAged, 80 and overDenmarkFemaleForced Expiratory VolumeGene-Environment InteractionHumansMaleMiddle AgedRegistriesChronic bronchitisCOPDHeritabilityLung functionTwin

Identifiers

PMID40579575
PMCPMC12204911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.