Evidence map›Paper›PMID 40579554›Full record

ArticleNature immunology2025

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis.

Morgan E Parker, Naren U Mehta, Tzu-Chieh Liao, William H Tomaszewski, Stephanie A Snyder, Julia Busch, Maria Ciofani

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. HEB collaborates with TCR signaling to upregulatebioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Morgan E Parker *Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0003-2610-8530
Naren U Mehta *Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0003-0829-3592
Tzu-Chieh LiaoDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.
William H TomaszewskiDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.
Stephanie A SnyderDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.
Julia BuschDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.
Maria CiofaniDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA. maria.ciofani@duke.edu.ORCID http://orcid.org/0000-0001-6472-5260

Funding

The role of TCR, ligand, and signal strength in human γδ T cell developmentP01AI102853 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI DAVID L. WIEST · 2014 to 2026
$26.3M
DUKE TRAINING GRANT IN DIGESTIVE DISEASES AND NUTRITIONT32DK007568 · NIDDK · DUKE UNIVERSITY · PI Katherine Garman, Rodger A. Liddle · 1988 to 2026
$5.6M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
The role of AP-1 family transcription factor networks in regulating TH17 cell effector identityR01GM115474 · NIGMS · DUKE UNIVERSITY · PI CIOFANI, MARIA · 2016 to 2024
$3.2M
Cis-regulatory mechanisms governing RORgt expression in type 3 lymphocytesF31AI181082 · NIAID · DUKE UNIVERSITY · PI Naren U Mehta · 2024 to 2026
$149k
Regulation of the type 1 program during ILC3 plasticityF31AI152457 · NIAID · DUKE UNIVERSITY · PI PARKER, MORGAN ELIZABETH · 2020 to 2021
$76k
NIAID NIH HHS F31 AI152457NIAID NIH HHS F31 AI181082NIAID NIH HHS P01 AI102853NIAID NIH HHS T32 AI052077NIDDK NIH HHS T32 DK007568NIGMS NIH HHS R01 GM115474U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) T32DK007568
6 · The paper itself

Abstract

Interleukin-17 (IL-17)-producing γδ T (Tγδ17) cells are innate-like mediators of intestinal barrier immunity. Although IL-17-producing helper T cell and group 3 innate lymphoid cell plasticity have been extensively studied, the mechanisms governing Tγδ17 cell effector flexibility remain undefined. Here, we combined type 3 fate mapping with single-cell ATAC-sequencing/RNA-sequencing multiome profiling to define the cellular features and regulatory networks underlying Tγδ17 cell plasticity. During homeostasis, Tγδ17 cell effector identity was stable across tissues, including for intestinal T-bet

Indexed as

Cell PlasticityImmunity, InnateReceptors, Antigen, T-Cell, gamma-deltaSalmonella InfectionsTh17 CellsTranscription Factor AP-1AnimalsInterferon-gammaInterleukin-17MiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Subfamily 1, Group F, Member 3Salmonella typhimuriumInterferon-gammaInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Receptors, Antigen, T-Cell, gamma-deltaTranscription Factor AP-1

Identifiers

PMID40579554
PMCPMC12335200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.