ArticlePediatric research2026
Implementation of active therapeutic hypothermia across a regional transport network for infants transferred for neonatal encephalopathy.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Contemporary Evidence on Interhospital Neonatal Transport as a Potentially Sepsis-Relevant Care Interval: A Scoping Review.Medicina (Kaunas, Lithuania) · 2026Article
- Implementation and evaluation of a quality improvement initiative for central venous catheter management in neonates undergoing therapeutic hypothermia for perinatal asphyxia.BMJ paediatrics open · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the introduction of servo-controlled therapeutic hypothermia (TH) by a regional transport service and referring centres for infants with hypoxic ischaemic encephalopathy (HIE). The primary objective was to compare the time to reach 33-34 °C target temperature (TT).
methodsThis is a retrospective cohort study of neonatal transfers for TH across a large UK regional network from 2011 to 2021. Three cohorts were identified for comparison, defined by the setting of TH initiation: referring 'Base' centre or during 'Transport' and by the TH method: passive
resultsA total of 315 infants were included. The Transport
conclusionsCompared with passive cooling, the introduction of transport and referring centre active TH improves temperature management of transferred infants with HIE, with more reaching therapeutic temperature within 6 h and fewer being overcooled. IMPACT: Early therapeutic hypothermia (TH) improves survival without disability for infants with hypoxic ischaemic encephalopathy (HIE). However, many infants are born in centres without servo-controlled TH and rely on passive cooling prior to transfer. This study demonstrates that the introduction of active TH by both the transport team and by referring centres is associated with significant improvements in time to reach target temperature, minimising overcooling and reducing transport stabilisation times. Investment in active TH provision by all birth centres and transport teams could be a cost-effective method to reduce birth-related brain injury and improve outcomes of infants with HIE.
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