ArticleMolecular psychiatry2025
A dorsal subiculum-medial mammillary body pathway for spatial memory.
Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Cross species single-nucleus characterization of mammillary body.Cell insight · 2026Article
- Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types.Hippocampus · 2026Article
- Fibronectin1-Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Encoding Patterned Spatial Behavior in the Subiculum.Hippocampus · 2026Review
- Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types.bioRxiv : the preprint server for biology · 2026Article
- Neutrophil-Membrane Biomimetic Hollow Mesoporous Silica Nanoparticles for Targeted Delivery of Imperatorin to Alleviate Cerebral Ischemia-Reperfusion Injury via Nrf2/ARE/Keap1 Pathway.International journal of nanomedicine · 2026Article
- Impairments of spatial memory retrieval via medial mammillary body dysfunction in Alzheimer's disease model.Translational psychiatry · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The dorsal subiculum (dSub) and medial mammillary body (MM) are essential components of the extended hippocampal system, heavily implicated in spatial memory processes. However, the exact function of the prominent dSub-to-MM projection has remained ambiguous. Here, integrating c-fos mapping, fiber photometry, optogenetic manipulations and behavioral paradigms, we found that the monosynaptic connection between dSub and MM, rather than collaterals to other regions, is not only involved in spatial memory retrieval but also highly vulnerable to perturbations on activity level in both directions. In addition, we mapped the single neuron projectome of MM-projecting dSub neurons using fluorescence micro-optical sectioning tomography (fMOST). Our study unveiled that the individual dSub neuron extend efferent connections to the bilateral MM neurons, while also exhibiting substantial collateral projections to the retrosplenial cortex (RSP) and entorhinal (ENT). Our findings shed light on previously unknown subtypes and organizational principles of projection neurons in the afferent circuitry of the MM, thereby elucidating the circuit mechanism underlying the contribution of the dSub-MM circuit to spatial memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.