Production and characterization of anti-bacterial metabolite(s) from Egyptian archaeological sites.

Aalaa A Youssef, Bassma H Elwakil, Doaa A Ghareeb, Zakia A Olama

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Aalaa A YoussefBotany and Microbiology Department, Faculty of Science, Alexandria University, Alexandria, 21500, Egypt. Alaa.Atef_PG@alexu.edu.eg.

Bassma H ElwakilMedical Laboratory Technology Department, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, Egypt.

Doaa A GhareebBio-Screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.

Zakia A OlamaBotany and Microbiology Department, Faculty of Science, Alexandria University, Alexandria, 21500, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial agents produced by Xenorhabdus spp. may hold the answer to novel antimicrobial agents. Antibacterial activity of some bacterial strains isolated from different Egyptian archaeological sites was evaluated. The most potent organism that reported high antibacterial activity was identified as Xenorhabdus nematophila. The produced bioactive compound was identified as xenortide using LC-MS and NMR studies. Optimization of xenortide's production was assessed using a central composite statistical design. The most effective fermentation factors were identified as carbon, nitrogen source concentrations and pH levels. Nano-xenortide was synthesized using the ball milling method, followed by its characterization and evaluation for its anticipated antibacterial and anticancer properties. Statistical analysis of the findings indicated that the produced nano-xenortide exhibited superior antibacterial efficacy. Furthermore, the assessment of its cytotoxicity revealed that nano-xenortide is a promising, safe candidate that can be used as an antibacterial and anti-colorectal-carcinoma agent.

Indexed as

Anti-Bacterial AgentsXenorhabdusAntineoplastic AgentsArchaeologyCell Line, TumorEgyptFermentationHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntineoplastic AgentsAntibacterialAnticancerBioactive producerNano-xenortideOptimizationXenorhabdus nematophila

Identifiers

PMID40579413

DOI10.1039/C8OB00452H

PMCPMC12205091

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.