ArticleKlinische Wochenschrift1985
[Alcohol and IgA in the kidney].
Article in Klinische Wochenschrift, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Glomerulonephritis as late manifestation of severe alpha 1-antitrypsin deficiency.The Clinical investigator · 1994Article
- Circulating IgA immune complexes and skin IgA deposits in liver disease. Relation to liver histopathology.Digestive diseases and sciences · 1988Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with chronic alcoholic liver disease show an increase in serum IgA with a preferential elevation of polymeric IgA. Furthermore, immune complexes containing IgA can be demonstrated. These changes may be explained by an alcohol-induced increase in intestinal permeability to macromolecular antigens leading to an IgA response, and by a decreased hepatic clearance of polymeric IgA not dependent on a secretory component. The prevalence of glomerular IgA deposits amounts to 50% in patients with alcoholic cirrhosis examined at autopsy. Polymeric and monomeric IgA, partially as immune complexes can be detected. However, urinary symptoms very rarely occur. The factors leading to glomerulonephritis following IgA deposition are poorly understood.
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