ArticleEuropean journal of endocrinology2025
Thyroid strain in pregnancy: a nationwide study of iodine nutrition and thyroglobulin among Faroese pregnant women.
Article in European journal of endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Evolving Concepts in Gestational Iodine Requirements.Healthcare (Basel, Switzerland) · 2026Review
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6 authors.
Funding
Abstract
objectiveAbnormal thyroid function is particularly problematic in pregnant women. Iodine is important to maintain normal thyroid function, and the World Health Organization (WHO) recommends a raised iodine intake in pregnant compared with non-pregnant adults. The raised iodine intake level from 100 to 150 µg/L includes a safety margin, and we hypothesized that the thyroid is not strained until urinary iodine concentration (UIC) is below 100 μg/L.
designNationwide cross-sectional study.
settingRoutine prenatal care at the National Hospital System of the Faroe Islands, 2020-2022.
participantsA total of 623 pregnant women, representing 63% of all pregnancies in the Faroe Islands during the study period, with no known thyroid disease. EXPOSURE: Iodine-containining dietary intake was assessed indirectly through urinary iodine concentration (UIC) measured on spot urine using the Sandell-Kolthoff reaction. MAIN OUTCOME: The primary outcomes were serum Thyroglobulin (s-Tg) and thyrotropin (TSH) concentration serving as indicators of potential thyroid strain and thyroid function. MEASURES: UIC and TSH was measured in all participants. sS-Tg was measured in a randomly selected subset of 236 participants.
resultsWomen were seen in median gestational week 20. None had elevated TSH; the median UIC was 108 µg/L, and the median s-Tg was 10.3 µg/L. Serum Tg differed only for the group with UIC below 50 µg/L (P = .02), but not when UIC was above 50 µg/L. TSH increased with higher UIC (P < .001). CONCLUSIONS AND RELEVANCE: Thyroglobulin levels increased only in the group of Faroese pregnant women with UIC below 50 µg/L, indicating that strain on the thyroid gland was seen with low UIC levels parallel to that of non-pregnant adults. Our results suggest that the UIC limit recommended in pregnancy may be overly strict and warrant reconsideration to balance health efficacy.
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