Evidence map›Paper›PMID 40579139›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[Neurospecific transmembrane protein 240 colocalizes with peroxisomes and activates Rho GDP dissociation inhibitor β].

Qiongqiong Hu, Wenpei Li, Lixia Xu, Ruilei Guan, Dongya Zhang, Jiaojiao Jiang, Ning Wang, Gaiqing Yang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Qiongqiong HuDepartment of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Wenpei LiDepartment of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Lixia XuDepartment of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Ruilei GuanDepartment of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Dongya ZhangDepartment of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Jiaojiao JiangDepartment of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Ning WangDepartment of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Gaiqing YangDepartment of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the subcellular localization and biological functions of transmembrane protein 240 (TMEM240).

methodsNCBI BLAST and TMHMM bioinformatics software were used for protein sequence analysis and prediction of transmembrane domain of TMEM240. Brain tissues from male C57BL/6 mice (18-20 days old) were examined for distribution of TMEM240 using

resultsHuman and mouse TMEM240 proteins share a 97.69% similarity in the protein sequences, and both are transmembrane proteins with two transmembrane domains. TMEM240 mRNA and protein were highly expressed in mouse brain tissues and cortical neurons. In isolated mouse cortical neurons, TMEM240 expression reached the peak level after primary culture for 9 days and distributed in scattered spots within the cells. In HepG2 cells, TMEM240 was characterized as intracellular membrane structures and showed 80% colocalization with peroxisomes. In Neuro-2a cells, TMEM240 overexpression caused significant enhancement of the expressions of Rho GDP dissociation inhibitor β (ARHGDIB) at both the mRNA and protein levels.

conclusionsTMEM240 is a novel intracellular subcellular structure specifically expressed in neurons with significant potential for targeted cellular function regulation.

Indexed as

Membrane ProteinsPeroxisomesAnimalsBrainHep G2 CellsHumansMaleMiceMice, Inbred C57BLNeuronsrho-Specific Guanine Nucleotide Dissociation InhibitorsMembrane Proteinsrho-Specific Guanine Nucleotide Dissociation InhibitorsneuronsperoxisomesRho GDP dissociation inhibitor βsubcellular localizationTMEM240

Identifiers

PMID40579139
PMCPMC12204824

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