Evidence map›Paper›PMID 40579110›Full record

ArticleJACC. Case reports2025

Embolic Stroke Due to a Large Noncoronary Sinus of Valsalva Aneurysm: A Multimodality Imaging Diagnosis.

Tyler C Miller, Stanley Wolfe, Dawn Smith, Jonathan Bond, Ruby Havistin, James D Mills, Jason Moreland, Lawrence Wei, James Mehaffey, Lakshmi Muthukumar

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tyler C MillerDepartment of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
Stanley WolfeDepartment of Cardiovascular and Thoracic Surgery, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
Dawn SmithDepartment of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
Jonathan BondDepartment of Anesthesiology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Ruby HavistinDepartment of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
James D MillsDepartment of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
Jason MorelandDepartment of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
Lawrence WeiDepartment of Cardiovascular and Thoracic Surgery, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
James MehaffeyDepartment of Cardiovascular and Thoracic Surgery, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
Lakshmi MuthukumarDepartment of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA. Electronic address: lakshmi.muthukumar@wvumedicine.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA sinus of Valsalva aneurysm (SoVA) is a rare cardiac condition caused by the dilation of a coronary sinus. If untreated, it can commonly lead to valvular dysfunction, arrhythmias, or rupture. CASE SUMMARY: A 71-year-old patient with hypertension and hyperlipidemia presented with an embolic stroke. Multimodality imaging revealed a large, 7.0 cm × 5.6 cm SoVA originating from the noncoronary sinus and causing nearly complete obstruction of the left atrium. The aneurysm was surgically repaired, and the patient made a full recovery. DISCUSSION: In rare cases, a stroke may be the initial presentation of a SoVA. The probable cause of the patient's stroke was attributed to thrombus formation within the SoVA that embolized. TAKE-HOME MESSAGES: This case emphasizes the importance of multimodality imaging for the diagnosis of a SoVA and for planning surgical repair. Additionally, clinicians should consider a SoVA in the differential diagnosis for a patient presenting with a stroke.

Indexed as

aortic root repaircomputed tomographycoronary angiographymultimodality cardiac imagingnoncoronary sinussinus of Valsalva aneurysmstroketransesophageal echocardiogramtransthoracic echocardiogram

Identifiers

PMID40579110
PMCPMC12273851

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