ArticleJACC. Case reports2025
Turning the Tide: Unraveling Aortic Dynamics and Patent Foramen Ovale in Platypnea-Orthodeoxia Syndrome.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Oxygen-Refractory Platypnea-Orthodeoxia Syndrome Requiring Urgent Surgical Closure: A Dynamic Assessment.JACC. Case reports · 2026Article
- Unexplained Positional Hypoxemia in an Elderly Patient: A Case of Platypnea-Orthodeoxia Syndrome.Cureus · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
backgroundPlatypnea-orthodeoxia syndrome (POS) is a rare disorder characterized by positional dyspnea and hypoxemia due to right-to-left shunting, often through a patent foramen ovale (PFO). It requires both an anatomical substrate and a functional trigger. CASE SUMMARY: A man in his 70s presented with acute cerebellar stroke, breathlessness, and profound hypoxia worsened by the upright position. He tested positive for COVID-19, and computed tomography demonstrated a small pulmonary embolism, aorta dilation, and steep aortic angulation. Transthoracic echocardiography with a bubble study confirmed the presence of a PFO with right-to-left shunting during the Valsalva maneuver. Percutaneous PFO closure resulted in clinical improvement and resolution of hypoxemia. DISCUSSION: This case highlights the interplay of PFO, aortic dilatation, and aortic angulation as key contributors to POS. Multimodal imaging is crucial for diagnosis and management. TAKE-HOME MESSAGE: POS should be considered in positional hypoxia cases, and imaging is essential for diagnosis and treatment planning.
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