ArticleIn vivo (Athens, Greece)
Effect of Zoledronic Acid Administration Timing on Metastatic Bone Tumors.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimBreast cancer frequently metastasizes to the bone, reducing quality of life and survival. Zoledronic acid (ZA), is used to treat bone metastasis; however, differences in efficacy depending on the timing of administration are not clear. This study investigated the effects of different timing of ZA administration in a mouse model of breast cancer bone metastasis. MATERIALS AND
methodsE0771 cells (1.0×10
resultsFive weeks after tumor-cell administration, bone destruction rate was significantly lower in all groups compared to the control group (
conclusionThe earlier ZA was administered, the more strongly it suppressed bone destruction and tumor cell proliferation.
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