ArticleIn vivo (Athens, Greece)
Do Breast Cancer Patients With Chemotherapy-induced Peripheral Neuropathy Have an Increased Risk of Radiation Dermatitis?
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimPatients with breast cancer scheduled for irradiation may present with peripheral neuropathy (PNP) caused by preceding taxane-based chemotherapy. Chemotherapy-related toxicity was suggested to be associated with a lower individual DNA repair capacity. A similar association was described for radiation-related toxicity. We investigated whether patients with taxane-induced PNP have an increased risk of radiation dermatitis. PATIENTS AND
methodsIn a retrospective cohort of 129 patients irradiated for breast cancer following taxane-based chemotherapy, PNP plus 14 characteristics were evaluated for associations with grade ≥2 radiation dermatitis.
resultsNo, mild, and moderate to severe PNP were associated with grade ≥2 dermatitis rates of 22.2%, 27.7%, and 37.8% (
conclusionA significant association between severity of PNP and grade ≥2 radiation dermatitis was not found, although grade ≥2 dermatitis occurred more frequently in patients with moderate to severe PNP.
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