Evidence map›Paper›PMID 40579008›Full record

ArticleIn vivo (Athens, Greece)

Impact of Adjuvant Chemotherapy Following Neoadjuvant Concurrent Chemoradiotherapy and Total Mesorectal Excision in Rectal Cancer.

Yu-Shih Liu, Jen-Kou Lin, Tzu-Chen Lin, Wei-Shone Chen, Shung-Haur Yang, Huann-Shenn Wang, Shih-Ching Chang, Yuan-Tzu Lan, Chun-Chi Lin, Hung-Hsin Lin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu-Shih LiuDivision of Colon and Rectal Surgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.; 184403@cch.org.tw.
Jen-Kou LinDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Tzu-Chen LinDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Wei-Shone ChenDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Shung-Haur YangDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Huann-Shenn WangDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Shih-Ching ChangDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Yuan-Tzu LanDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Chun-Chi LinDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Hung-Hsin LinDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.
Jeng-Kai JiangDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study investigated the efficacy of adjuvant chemotherapy (ACT) after total mesorectal excision (TME) for rectal cancer in patients who responded well to neoadjuvant concurrent chemoradiotherapy (nCCRT). PATIENTS AND

methodsThis retrospective study included patients with rectal cancer treated at Taipei Veterans General Hospital (2009-2017). Among 302 patients who underwent nCCRT and TME, 178 good responders [pathologic complete response (pCR), pT1, or pT2] were analyzed. Patients were grouped based on ACT administration. Primary outcomes included disease-free survival (DFS) and recurrence. Kaplan-Meier survival analysis and Cox proportional hazards regression were used to assess ACT efficacy.

resultsThe ACT group (n=96) had poorer baseline disease characteristics, including higher initial clinical T and N stages. However, recurrence rates did not differ significantly between ACT and non-ACT groups (23.2%

conclusionThe role of ACT remains inconclusive after TME for rectal cancer in patients who respond well to nCCRT. Surgical pT stage, particularly pT3 and pT4, remain a significant predictor of recurrence, emphasizing its importance in risk stratification.

Indexed as

Rectal NeoplasmsAdultAgedChemoradiotherapyChemotherapy, AdjuvantCombined Modality TherapyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesTreatment Outcomeadjuvant chemotherapy (ACT)neoadjuvant concurrent chemoradiotherapy (nCCRT)Rectal cancertotal mesorectal excision (TME)

Identifiers

PMID40579008
PMCPMC12223617

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.