ArticleIn vivo (Athens, Greece)
Survival Predictors in Obstructive Colorectal Cancer: A Combined Clinical, Inflammatory, and Histopathological Approach.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A predictive nomogram model for overall survival in obstructive colorectal cancer based on clinical and laboratory indicators.Journal of gastrointestinal oncology · 2026Article
- Inflammatory indices as perioperative predictors in colorectal cancer: bridging population data and surgical decision-making.International journal of surgery (London, England) · 2026Article
- Taxonomic Profiling of Systemic Inflammatory Parameters as Predictors of Tumor Progression in Primary Colorectal Cancer.Journal of clinical medicine · 2025Article
- Analysis of clinical characteristics of 117 cases of ischemic colitis.BMC gastroenterology · 2025Article
- Lenvatinib Suppresses Colorectal Cancer Cell Growth, Migration, and InvasionIn vivo (Athens, Greece)Article
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Authors and funding
2 authors.
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Abstract
BACKGROUND/
aimObstructive colorectal cancer (oCRC) accounts for a significant proportion of colorectal malignancies and is associated with poor prognosis and higher perioperative morbidity. Inflammation-based biomarkers have emerged as potential predictors of survival in various cancers. However, their prognostic role in oCRC remains unclear. PATIENTS AND
methodsThis retrospective study included patients who underwent surgery for histopathologically confirmed oCRC at Sakarya University Training and Research Hospital between January 2015 and February 2024. Preoperative systemic inflammatory markers-C-reactive protein-to-albumin ratio (CAR), lymphocyte-to-C-reactive protein ratio (LCR), prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic inflammatory index (SII), and HALP score-were analyzed. Overall survival was recorded, and statistical analyses were performed.
resultsAmong the inflammatory markers, CAR, LCR, and PNI were significantly associated with overall survival at 1, 3, and 5 years (
conclusionPreoperative systemic inflammatory markers, particularly LCR, CAR, and PNI, are valuable prognostic indicators in patients with oCRC. These easily obtainable markers may help guide clinical decision-making and improve individualized patient management.
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