Evidence map›Paper›PMID 40578881›Full record

ArticleBMJ open2025

Multicomponent intervention for controlling hypertension in the adult rural population of Pakistan: a protocol for a hybrid type III implementation-effectiveness cluster randomised controlled trial.

Imran Naeem, Aysha Almas, Aziz Sheikh, Catherine Hewitt, Hajra Khwaja, Saima Afaq, Saira Bukhari, Sajid Soofi, Salim S Virani, Sawera Hanif and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06726057 (A Multi-component Intervention for Controlling Hypertension in the Adult Rural Population of Pakistan), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06726057 naactive not recruitingnot on this map

A Multi-component Intervention for Controlling Hypertension in the Adult Rural Population of Pakistan: a Protocol for a Hybrid Type III Implementation-effectiveness Cluster Randomized Controlled Trial

TypeinterventionalSponsorAga Khan UniversityRan2024 to 2028Enrolled3,459ConditionsHypertensionArmsImlementation strategies in conjunction with multicomponent hypertension intervention, Multicomponent hypertension intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Imran NaeemCommunity Health Sciences Department, Aga Khan University Medical College Pakistan, Karachi, Sindh, Pakistan.ORCID http://orcid.org/0000-0002-9487-1303
Aysha AlmasMedicine, Aga Khan University, Karachi, Sindh, Pakistan.ORCID http://orcid.org/0000-0001-7146-7183
Aziz SheikhUniversity of Oxford Division of Public Health and Primary Health Care, Oxford, UK.ORCID http://orcid.org/0000-0001-7022-3056
Catherine HewittHealth Sciences, The University of York, York, UK.
Hajra KhwajaMedicine, Aga Khan University, Karachi, Sindh, Pakistan.
Saima AfaqDepartment of Health Sciences, University of York, University of York, York, UK.ORCID http://orcid.org/0000-0002-9080-2220
Saira BukhariMedicine, Aga Khan University, Karachi, Sindh, Pakistan.
Sajid SoofiPediatrics and Child Health, The Aga Khan University, Karachi, Sindh, Pakistan.ORCID http://orcid.org/0000-0003-4192-8406
Salim S ViraniAga Khan University, The Aga Khan University, Karachi, Sindh, Pakistan.
Sawera HanifMedicine, Aga Khan University, Karachi, Sindh, Pakistan.
Shiraz HashmiMedicine, Aga Khan University, Karachi, Sindh, Pakistan.
Simon WalkerCentre for Health Economics, The University of York, York, UK.
Zulfiqar Ahmed BhuttaDivision of Women and Child Health, Aga Khan University, Karachi, Sindh, Pakistan.
Kamran SiddiqiInstitute of Health Sciences, University of York, York, UK.ORCID http://orcid.org/0000-0003-1529-7778
Zainab SamadMedicine, Aga Khan University, Karachi, Sindh, Pakistan samad.zainab@aku.edu.ORCID http://orcid.org/0000-0003-2422-3199

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThough prior trials have shown the effectiveness of community-based hypertension detection and care delivery models, their adoption and translation to practice has been slow. In this study, we will develop and test strategies for the implementation and scale-up of a proven multicomponent hypertension intervention (MCHI) in Pakistan that comprises health education, blood pressure (BP) monitoring and referrals by lady health workers (LHWs) and hypertension management by physicians in primary care settings. METHODS AND ANALYSIS: In this 24-month hybrid type III implementation-effectiveness cluster-randomised controlled trial, we will recruit 3000 adult hypertensive patients from two rural districts of Pakistan. We will engage public health sector managers, physicians and LHWs and use the ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Ethics Review Committee of Aga Khan University Pakistan (ERC # 2023-9084-26739). Findings will be reported to: (1) study participants; (2) funding body and institutes collaborating and supporting the study; (3) provincial and district health departments to inform policy; (4) presented at local, national and international conferences and (5) disseminated by peer-review publications TRIAL REGISTRATION NUMBER: NCT06726057.

Indexed as

HypertensionAdultFemaleHealth EducationHumansMalePakistanPrimary Health CareRandomized Controlled Trials as TopicReferral and ConsultationRural PopulationBlood PressureCardiovascular DiseaseHypertensionRandomized Controlled Trial

Identifiers

PMID40578881
PMCPMC12207168

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.