Evidence map›Paper›PMID 40578878›Full record

ArticleBMJ open2025

Effect of acupuncture on endometrial receptivity in women with thin endometrium: study protocol for a single-centre, randomised, sham-controlled trial.

Xiaoyan Wang, Yigong Fang, Huanfang Xu, Li Yang, Tian Hang, Jiashan Li, Pengfei Du, Chenchen Su, Xin Liu, Weixin Li and 1 more

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoyan WangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.ORCID http://orcid.org/0009-0000-1665-2431
Yigong FangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China huanfang_xu@126.com fangyigong@163.com.ORCID http://orcid.org/0000-0001-7879-2843
Huanfang XuInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China huanfang_xu@126.com fangyigong@163.com.ORCID http://orcid.org/0000-0002-0005-5648
Li YangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-6684-2567
Tian HangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-3413-6822
Jiashan LiInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-6567-6402
Pengfei DuInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Chenchen SuInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-3645-3306
Xin LiuInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Weixin LiInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.ORCID http://orcid.org/0009-0001-0100-3460
Yaoyao ZhuInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThin endometrium poses a major therapeutic challenge in assisted reproductive technologies by compromising pregnancy success and live birth outcomes. A substantial proportion of patients remain refractory to existing therapies. Preliminary evidence suggests acupuncture may improve endometrial thickness (EMT). This study aims to assess the effect of acupuncture against sham acupuncture for women with thin endometrium. METHODS AND ANALYSIS: This study is a single-centre, randomised, sham-controlled trial conducted at a specialised acupuncture hospital in Beijing, China. A total of 120 women with thin endometrium will be randomised (1:1) to receive 36 sessions of acupuncture or sham acupuncture over 12 weeks. The primary outcome is the EMT at week 12. Secondary outcomes are endometrial pattern, uterine arterial blood flow parameters (Pulsatility Index, Resistance Index and the ratio of peak systolic to end-diastolic blood flow velocities), endometrium blood flow, serum oestradiol concentration, clinical pregnancy rate and Self-Rating Anxiety Scale Scores. ETHICS AND DISSEMINATION: This study has been approved by the ethics committee of the Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences (approval no.: S2024-04-23-1). Each participant will be required to provide written informed consent before enrolment. Findings will be disseminated through peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: ITMCTR2024000053.

Indexed as

Acupuncture TherapyEndometriumAdultChinaFemaleHumansPregnancyPregnancy RateRandomized Controlled Trials as TopicClinical TrialGenitourinary MedicineRandomized Controlled TrialSubfertility

Identifiers

PMID40578878
PMCPMC12207127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.