Evidence map›Paper›PMID 40578862›Full record

ArticleBMJ open2025

Outcomes of patient and public involvement in the development of the Cognitive Decline after Brain Radiosurgery (CoDe B-Rad) study: refining the research question and methodology.

Anna Bangiri, Adele Horobin, Julia Baker, Stefan Pszczolkowski, Stefanie Thust, Paul S Morgan

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06466720 (Measuring and Mapping Cognitive Decline After Brain Radiosurgery), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06466720 active not recruitingnot on this map

Measuring and Mapping Cognitive Decline After Brain Radiosurgery: a Pilot Study

TypeobservationalSponsorUniversity of NottinghamRan2024 to 2026Enrolled80ConditionsBrain Metastases, Meningiomas, Stereotactic Radiosurgery, Cognitive DeclineArmsNeurocognitive testing, Quality of Life questionnaire, Stereotactic radiosurgery
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna BangiriRadiotherapy North, Nottingham University Hospitals NHS Trust - City Campus, Nottingham, UK anna.bangiri1@nottingham.ac.uk.ORCID http://orcid.org/0000-0001-6242-9476
Adele HorobinUniversity of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-7120-4612
Julia BakerPatient and Public Involvement Contributor, Doncaster, UK.
Stefan PszczolkowskiUniversity of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-5859-3190
Stefanie ThustRadiological Sciences, Mental Health and Clinical Neuroscience, University of Nottingham School of Medicine, Nottingham, UK.ORCID http://orcid.org/0000-0001-5136-6000
Paul S MorganDivision of Clinical Neuroscience, University of Nottingham School of Medicine, Nottingham, UK.ORCID http://orcid.org/0000-0002-5870-1446

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectivesPatient and public involvement (PPI) was sought in the development of the protocol for the Cognitive Decline after Brain Radiosurgery (CoDe B-Rad) study, which aims to identify potential side effects of stereotactic radiosurgery (SRS). PPI served to refine the research question and methodology.

designPPI.

settingPPI conducted online with people based in the UK. The CoDe B-Rad study is running in regional National Health Service tertiary care in the UK and is currently nearing recruitment completion.

participantsPatients and carers with lived experiences of brain radiotherapy. Contributors were identified through national charities. PROCEDURES: Initial focus groups were planned, but participation proved challenging. Instead, online questionnaires, one-to-one discussions and participation in support groups were completed.

resultsAll contributors experienced changes to their cognition and/or quality of life (QoL) after radiotherapy. Quantifying the side effects of SRS and minimising them were identified as a research gap. Discussion group participation proved challenging. PPI plans were altered to accommodate the physical and mental needs of contributors. It was decided to combine the Montreal Cognitive Assessment along with European Organisation for Research and Treatment in Cancer QLQ-C30 and BN20 to capture cognitive status and QoL of patients with brain metastases and meningiomas after SRS. Patients/carers recommended for sessions to be restricted to 30 min and testing to be offered face-to-face, online, in hospital or at patients' homes. Coproduction was not achievable with our patient population but that did not diminish the input of contributors nor the impact it had on designing the study protocol.

conclusionsIn cancer research, diligent considerations are required to ensure the suitability of involvement methods for this vulnerable population. Flexibility and adaptability of draft PPI plans are essential to achieve meaningful contributions. The protocol of the ongoing CoDe B-Rad study was positively shaped by people with lived experiences of brain radiotherapy. TRIAL REGISTRATION NUMBER: NCT06466720 (CoDe B-Rad study).

Indexed as

Brain NeoplasmsCognitive DysfunctionPatient ParticipationRadiosurgeryFemaleFocus GroupsHumansMaleObservational Studies as TopicQuality of LifeResearch DesignSurveys and QuestionnairesUnited KingdomCognitionONCOLOGYPatient ParticipationPatient Reported Outcome MeasuresQuality of LifeRadiosurgery

Identifiers

PMID40578862
PMCPMC12207110

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.