Evidence map›Paper›PMID 40578777›Full record

ArticleAmerican heart journal2025

Utilization and spending on lipid lowering therapies in medicaid from 2018 to 2022.

Alexander Beschloss, Rishi K Wadhera, Andrew S Oseran

Abstract read
In one paragraph

Article in American heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Bempedoic Acid: From Guidelines to the Real World.Journal of lipid and atherosclerosis · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander BeschlossDepartment of Medicine, Massachusetts General Hospital, Boston, MA.
Rishi K WadheraRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Boston, MA; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA.
Andrew S OseranRichard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Boston, MA; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address: aoseran@bidmc.harvard.edu.

Funding

Cardiovascular Health of Low-Income Working-Age Adults in the US: Health Care Access, Policy, and the PandemicR01HL164561 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Rishi Kumar Wadhera · 2022 to 2026
$3.7M
Strategies to Improve the Cardiovascular Health of Rural Working-Age Adults in the United StatesR01HL174549 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Rishi Kumar Wadhera · 2024 to 2026
$2.3M
Leveraging SNAP Policies to Improve the Cardiovascular Health of Low-Income Adults in the United StatesR01NR021686 · NINR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Rishi Kumar Wadhera · 2024 to 2026
$2.0M
Evaluating Policies to Improve Heart Failure Outcomes in MedicareK23HL173636 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Andrew Seymour Oseran · 2024 to 2026
$507k
NHLBI NIH HHS K23 HL173636NHLBI NIH HHS R01 HL164561NHLBI NIH HHS R01 HL174549NINR NIH HHS R01 NR021686
6 · The paper itself

Abstract

backgroundTo determine how utilization and spending on lipid lowering medications in Medicaid changed between 2018 and 2022.

methodsRetrospective, cross-sectional study of utilization and spending on 32 lipid lowering drug formulations (18 brand-name, 14 generic) using the Medicaid Spending by Drug Dataset (2018-2022).

resultsThe study included over 115 million prescription fills in the Medicaid program. Between 2018 and 2022, annual prescription fills for lipid lowering medications increased 1.2%, from 22.7 million per year to 22.9 million per year, while annual Medicaid spending on these medications increased 13.2%, from $348.3 million to $394.4 million per year. Annual statin utilization remained stable over the study period (20.4 million fills in 2018 compared to 20.3 million fills in 2022), while spending on statins decreased (from $243.9 million to $228.3 million). Conversely, annual prescription fills and spending for PCSK9 inhibitors (7,617 fills and $8.9 million to 121,737 fills and $65.7 million), icosapent ethyl (32,527 fills and $10.2 million to 180,291 fills and $50.2 million), and bempedoic acid (from 494 fills and $215,499 to 4,619 fills and $2.2 million) all increased between 2018 and 2022.

conclusionBetween 2018 and 2022, annual prescription fills for lipid lowering therapies in Medicaid remained stable while spending on these medications increased, driven by increased utilization of PCSK9 inhibitors, icosapent ethyl, and bempedoic acid. As Medicaid budgets face escalating financial pressure-and the burden of cardiovascular disease increases among low-income adults in Medicaid-it is critical that policymakers continue to monitor utilization and spending on existing and novel high-cost medical therapies.

Indexed as

Drug UtilizationHealth ExpendituresHypolipidemic AgentsMedicaidCross-Sectional StudiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsRetrospective StudiesUnited StatesHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic Agents

Identifiers

PMID40578777
PMCPMC13526900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.