Evidence map›Paper›PMID 40578670›Full record

ArticleJournal of molecular biology2025

Human Plastins are Novel Cytoskeletal pH Sensors with a Reduced F-actin Bundling Capacity at Basic pH.

Lucas A Runyan, Elena Kudryashova, Richa Agrawal, Mubarik Mohamed, Dmitri S Kudryashov

Abstract read
In one paragraph

Article in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lucas A RunyanDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Elena KudryashovaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Richa AgrawalDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Mubarik MohamedDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Dmitri S KudryashovDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA. Electronic address: kudryashov.1@osu.edu.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Molecular and cellular mechanisms of the actin cytoskeleton organization and functionR01GM145813 · NIGMS · OHIO STATE UNIVERSITY · PI KUDRYASHOV, DMITRI · 2022 to 2025
$1.7M
NCI NIH HHS P30 CA016058NIGMS NIH HHS R01 GM145813
6 · The paper itself

Abstract

Intracellular pH (pH

Indexed as

Actin CytoskeletonActinsCytoskeletonMembrane GlycoproteinsMicrofilament ProteinsHumansHydrogen-Ion ConcentrationProtein BindingActinsMembrane GlycoproteinsMicrofilament Proteinsplastinactin cytoskeletonfimbrinintracellular pHLCP1plastinPLS2PLS3

Identifiers

PMID40578670
PMCPMC12309418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.