Evidence map›Paper›PMID 40578619›Full record

ArticleNeuroscience letters2025

Sex-specific cell death mechanisms in rodent sub-acute and chronic stroke.

Alexandra J White, Latavya Chintada, Hugh H Chan, Brittany Md Fisher, Nymisha Mandava, Olivia Hogue, Andre G Machado, Kenneth B Baker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Hemodynamic and Electrophysiological Progression of the Rose Bengal Photothrombotic Stroke Model in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexandra J WhiteDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA.
Latavya ChintadaDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Hugh H ChanDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Brittany Md FisherDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Nymisha MandavaDepartment of Quantitative Health, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Olivia HogueDepartment of Quantitative Health, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Andre G MachadoNeurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Kenneth B BakerDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: bakerk6@ccf.org.

Funding

Cerebellar deep brain stimulation to enhance chronic post-stroke rehabilitationR01NS105899 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2018 to 2022
$2.5M
NINDS NIH HHS R01 NS105899
6 · The paper itself

Abstract

To characterize subacute and chronic effects of sex as a biological variable in the severity and pathophysiology of stroke, ten male and ten female animals (>230 g and 2-4 months old) underwent photothrombotic infarction at the sensorimotor cortex. Lesion volume was calculated two- and four-weeks post-stroke (5 animals/sex/timepoint). The perilesional area was stained for active caspase-8, apoptosis-inducing factor (AIF), and Iba-1 expression at each timepoint. Males demonstrated significantly larger lesion volume than females at both two- (male: 11.2 mm

Indexed as

Cell DeathSex CharacteristicsStrokeAnimalsApoptosisApoptosis Inducing FactorCaspase 8Chronic DiseaseFemaleMaleRatsRats, Sprague-DawleyApoptosis Inducing FactorCaspase 8AIFApoptosisCaspase 8ParthanatosPhotothrombotic strokeSex difference

Identifiers

PMID40578619
PMCPMC13231187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.