Evidence map›Paper›PMID 40578353›Full record

ArticleStem cell reports2025

Transparency and ongoing communication with participants in brain organoid research: Consensus of an interdisciplinary working group.

Betty Cohn, Megan Doerr, Pamela Feliciano, Stephanie M Fullerton, Saskia Hendriks, Soren Holm, Insoo Hyun, Karin Jongsma, Karen M Meagher, M Elizabeth Ross and 3 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Betty CohnInstitute for Public Health Genetics, University of Washington, Seattle, WA, USA.
Megan DoerrSage Bionetworks, Seattle, WA, USA.
Pamela FelicianoDivision of Genetics & Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Stephanie M FullertonInstitute for Public Health Genetics, University of Washington, Seattle, WA, USA; Department of Bioethics & Humanities, University of Washington School of Medicine, Seattle, WA, USA.
Saskia HendriksNIH Clinical Center Department of Bioethics, Bethesda, MD, USA.
Soren HolmCentre for Social Ethics and Policy, University of Manchester, Manchester, UK; Center for Medical Ethics, HELSAM, University of Oslo, Oslo, Norway.
Insoo HyunMuseum of Science, Boston, MA, USA; Center for Bioethics, Harvard Medical School, Boston, MA, USA.
Karin JongsmaBioethics and Health Humanities, University Medical Center, Utrecht University, Utrecht, the Netherlands.
Karen M MeagherBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA.
M Elizabeth RossCenter for Neurogenetics, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Jason L SteinDepartment of Genetics and UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sharon F TerryGenetic Alliance, Damascus, MD, USA.
Katherine E MacDuffieTreuman Katz Center for Pediatric Bioethics and Palliative Care, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: kate.macduffie@seattlechildrens.org.

Funding

The experience of human subjects with brain organoid researchR00MH125328 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI MACDUFFIE, KATE E. · 2022 to 2024
$711k
NIMH NIH HHS R00 MH125328
6 · The paper itself

Abstract

Stem cell-based models of the human brain benefit from biospecimens that can be used for a broad range of future research. But current regulations do not address the desire of research participants to remain engaged beyond initial biospecimen donation. We present practicable strategies for engaging participants while preserving scientific potential.

Indexed as

Biomedical ResearchBrainCommunicationOrganoidsHumansInformation DisseminationInformed ConsentInterdisciplinary ResearchSpecimen Handling

Identifiers

PMID40578353
PMCPMC12447313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.