Trial reportRheumatology (Oxford, England)2025
An educational tool to improve PREeclamPsia knowledge and Aspirin adheRence in lupus prEgnancies: the PREPARE trial.
Trial report in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03749044 (Aspirin Patterns of Use and Adherence for Prevention of Preeclampsia in SLE Pregnancies), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Aspirin Patterns of Use and Adherence for Prevention of Preeclampsia in SLE Pregnancies
Who cites it
2 citing papers in PubMed.
- Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches.Arthritis care & research · 2026Review
- Elevated pre-eclampsia risk in lupus nephritis and antiphospholipid syndrome: a nationwide Spanish registry analysis.Rheumatology (Oxford, England) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
objectiveTo evaluate the effect of an educational tool on preeclampsia knowledge, as well as aspirin (ASA) use and adherence in pregnant SLE women.
methodsA two-arm parallel randomized controlled trial was conducted recruiting pregnant SLE women up to 17 weeks' gestation. Participants were randomly assigned to receive either usual-care alone or usual-care plus the tool (laminated card incorporating infographics on preeclampsia in SLE and ASA for prevention). The primary outcome was difference in preeclampsia knowledge scores at the second-trimester visit.
resultsOf 73 women included, 38 were randomized to the intervention. In the primary analysis of ongoing pregnancies, increase in the mean preeclampsia knowledge scores was 4.0 points (95% CI: 2.4, 5.6) in the intervention group and 2.0 points (95% CI: 0.3, 3.9) in controls, with a mean difference of 1.8 points higher (95% CI: -0.5, 4.2) favouring the intervention. Including end-of-pregnancy scores of women with fetal loss (six in each group), the difference was 4.8 points (95% CI: 3.3, 6.9) in the intervention group and 1.9 points (95% CI: 0.3, 3.6) in controls, with a mean increase of 2.5 points (95% CI: 0.3, 4.8) more for the intervention. Using electronic pharmacy data, there was a trend for higher ASA adherence in the intervention group (81%) vs controls (65%; difference 15%, 95% CI: -9, 37%).
conclusionWomen with SLE who received an educational tool had greater improvement in preeclampsia knowledge vs controls. This tool may improve ASA use in SLE pregnancies and help optimize outcomes.
trial registrationClinicalTrials.gov, http://clinicaltrials.gov, NCT03749044.
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