Evidence map›Paper›PMID 40578137›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2025

Using solid-state MRI and a double-tuned RF coil to quantify bone matrix and mineral densities in rat bones.

Victor B Kassey, Matthias Walle, Diana Yeritsyan, Daniel V Kassey, Yaotang Wu, Brian D Snyder, Edward K Rodriguez, Jerome L Ackerman, Ara Nazarian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A CombinedAnnals of biomedical engineering · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victor B KasseyMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA; Department of Orthopaedic Surgery, Boston Children's Hospital & Harvard Medical School, Boston, MA, USA; Athinoula Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA.
Matthias WalleMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA.
Diana YeritsyanMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA.
Daniel V KasseyMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA; Athinoula Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA.
Yaotang WuDepartment of Orthopaedic Surgery, Boston Children's Hospital & Harvard Medical School, Boston, MA, USA; Athinoula Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA.
Brian D SnyderMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA; Department of Orthopaedic Surgery, Boston Children's Hospital & Harvard Medical School, Boston, MA, USA.
Edward K RodriguezMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA.
Jerome L AckermanAthinoula Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
Ara NazarianMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA; Department of Orthopaedic Surgery, Yerevan State Medical University, Yerevan, Armenia. Electronic address: anazaria@bidmc.harvard.edu.

Funding

Bone Quality Assessment with a Novel Three-Bore Magnet Extremity MRI ScannerR01AR075077 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI ACKERMAN, JEROME L · 2020 to 2025
$2.4M
Assessment of Bone Composition Through a Novel Liquid/Solid State MRI MethodR00AR057093 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NAZARIAN, ARA · 2012 to 2014
$730k
Assessment of Bone Composition Through a Novel Liquid/Solid State MRI MethodK99AR057093 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NAZARIAN, ARA · 2010 to 2011
$181k
NIAMS NIH HHS K99 AR057093NIAMS NIH HHS R00 AR057093NIAMS NIH HHS R01 AR075077
6 · The paper itself

Abstract

Quantitative information on the composition of bone, specifically the content of calcium phosphate mineral and organic matrix, is essential for accurate diagnosis of metabolic bone diseases such as osteoporosis, osteomalacia, and renal osteodystrophy, as well as for differentiating among these conditions. Conventional MRI fails to provide this information because these substances are solid and, therefore, yield no signal in conventional MRI scans, which typically employ spin or gradient echoes. In this report, we show how phosphorus and proton solid-state MRI yield the desired compositional information in bone specimens with ZTE and WASPI pulse sequences, respectively, coupled with the use of a two-port double-tuned solenoidal RF coil. Electrical network simulations and construction details of the RF coil are detailed. Electrical performance was simulated using QUCS software to find the circuit component values that minimize reflected power and maximize interport isolation. Phantoms of known composition, as well as ex vivo femurs from normal, low bone density, and vitamin D-deficient rats, were included in the study. A simple correction for B

Indexed as

Bone and BonesBone DensityBone MatrixMagnetic Resonance ImagingAnimalsEquipment DesignFemurPhantoms, ImagingRadio WavesRatsRats, Sprague-DawleyBone MRIDouble-tuned single RF coilMetabolic bone diseaseOsteomalaciaOsteoporosisSolid-state MRI

Identifiers

PMID40578137
PMCPMC12801613

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.