Evidence map›Paper›PMID 40578025›Full record

ArticleRedox biology2025

Exercise-induced mitochondrial protection in skeletal muscle of ovariectomized mice: A myogenic E

Xu Tian, Yi Hu, Tao Li, Fangfang Yu, Tingting Li, Xiangyang Tian, Yiwei Feng, Qiuling Zhong, Yifan Meng, Wei Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xu TianSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Yi HuSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Tao LiSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Fangfang YuSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Tingting LiSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Xiangyang TianSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Yiwei FengSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Qiuling ZhongSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Yifan MengSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Wei ChenSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Rengfei ShiSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China. Electronic address: rfshi@sus.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkeletal muscle, a 17β-estradiol (E

methodsFemale C57BL/6J mice (8-week-old) were divided into Sham, OVX, and OVX + ET groups (N = 12). OVX mice underwent bilateral ovariectomy, with the OVX + ET group performing 8 weeks of treadmill exercise starting 10 weeks post-surgery. Functional tests (grip strength, fatigue resistance) and gastrocnemius analyses (morphology, mitochondrial function, E2/antioxidant levels, and protein expression) were conducted. Parallel experiments in muscle-specific aromatase knockout (MS-ARO-CKO) mice included E2 supplementation via subdermal pellets.

results18 weeks after ovariectomy (OVX), C57BL/6J mice exhibited significant reductions in grip strength (∼30 %), rotarod performance (∼57 %), and grid hanging performance (∼92 %). Concomitantly, OVX led to marked decreases in mitochondrial respiration (p < 0.05) and antioxidant capacity (p < 0.05) in the gastrocnemius muscle, accompanied by alterations in mitochondrial quality control and antioxidant signaling proteins (p < 0.05). Exercise intervention effectively attenuated these OVX-induced deficits, accompanied by a 66 % increase in E

conclusionsOur findings demonstrate that the protective effects of exercise on skeletal muscle mitochondria involve multiple mechanisms, independent myogenic E

Indexed as

EstradiolMitochondriaMitochondria, MuscleMuscle, SkeletalPhysical Conditioning, AnimalAnimalsAromataseFemaleMiceMice, Inbred C57BLMice, KnockoutOvariectomyAromataseEstradiolExercise trainingMitochondrial functionMuscle weaknessMyogenic 17β-estradiol

Identifiers

PMID40578025
PMCPMC12266561

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.