ArticleScience advances2025
Dorsal raphe nucleus controls motivation-state transitions in monkeys.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Brain activity, disruption and connectivity comparisons identify origins of human metacognition in other primates.Nature human behaviour · 2026Article
- Activity in human dorsal raphe nucleus signals changes in behavioural policy.Nature communications · 2026Article
- Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity.Nature communications · 2025Article
- Fundamental features of social environments determine rate of social affiliation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Non-invasive Ultrasonic Neuromodulation of the Human Nucleus Accumbens Impacts Reward Sensitivity.bioRxiv : the preprint server for biology · 2025Article
- Early versus late noise differentially enhances or degrades context-dependent choice.Nature communications · 2025Article
- Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology.Neuron · 2024Article
- The future of transcranial ultrasound as a precision brain interface.PLoS biology · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The dorsal raphe nucleus (DRN) is an important source of serotonin in the brain, but fundamental aspects of its function remain elusive. Here, we present a combination of minimally invasive recording and disruption studies to show that DRN brings about changes in motivation states. We use recently developed methods for identifying temporal patterns in behavior to show that monkeys change their motivation depending on the availability of rewards in the environment. Distinctive patterns of DRN activity occur when monkeys transition between a high-motivation state occupied when rewards are abundant, to a low-motivation state engendered by reward scarcity. Disrupting DRN diminishes sensitivity to the reward environment and perturbs transitions in motivational states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.