Observational studyPloS one2025
Needs assessment and preparedness of the primary health care network for scaling-up preventive tuberculosis treatment in 5 Brazilian capitals.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Delivering and beyond: insights about the ExpandTPT community advisory board experience in Brazil.Journal of global health · 2026Article
- Scaling Up Tuberculosis Preventive Treatment in the Brazilian Amazon (2016-2024): a Programmatic Report on Multi-sector Integration in Surveillance, Health Services and Academia.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Effect of successive tuberculin skin test readings on healthcare professionals' proficiency: an operational observational study in five high-tuberculosis-burden Brazilian municipalities, 2023-2024.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Observational
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to conduct a needs and preparedness assessment of public primary care units to scale up tuberculosis infection diagnosis and tuberculosis preventive treatment in 5 Brazilian capitals. This observational operational study was carried out across five Brazilian high tuberculosis-burden cities. Clinics with at least one monthly new tuberculosis case were included. Data on Purified Protein Derivative (PPD) storage, tuberculin skin testing (TST) and interferon-gamma release assay (IGRA) availability, personnel qualified for performing TST, radiological facilities and tuberculosis preventive treatment drug availability, were gathered between August 2023 and January 2024. Out of 285 clinics included, 78% (CI95%: 73%-82%) did not offer TST on-site, with only 28% (CI95%: 22%3%) having staff qualified to perform TST, and 35% (CI95%: 29%-40%) lacking dedicated refrigerators for PPD storage. Most (97%, CI95%: 94%-99%) clinics did not collect IGRA testing, with an average distance of 6.7 km (CI95%: 5%-7%) to IGRA labs and a turnaround time of 11.7 days (CI95%: 9%13%) for results. Most (87%, CI95%: 83%-91%) do not offer on-site radiological testing. The primary care network was unprepared to scaling up tuberculosis infection testing. Key issues include unavailability of TST mainly because of insufficient qualified personnel. Without accelerated qualification of staff for TST, scaling up tuberculosis preventive treatment will be impossible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.