ArticleJournal of veterinary internal medicine
Randomized Open-Label Clinical Trial Comparing Prednisolone and Cyclosporine With a Nonrandomized Active Control for Treating Presumed Chronic Pancreatitis in Cats.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Serial measurement of serum pancreatic lipase immunoreactivity and trypsin-like immunoreactivity concentrations in cats with chronic enteropathy.Journal of feline medicine and surgery · 2026Article
- Longitudinal comparison of serum pancreatic lipase activity and pancreatic lipase immunoreactivity with clinical signs in cats with suspicion of pancreatitis.Journal of feline medicine and surgery · 2026Article
- Randomized Open-Label Clinical Trial Comparing Prednisolone and Cyclosporine With a Nonrandomized Active Control for Treating Presumed Chronic Pancreatitis in Cats.Journal of veterinary internal medicineArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent management for chronic pancreatitis in cats is largely symptomatic. Anecdotal reports suggest that immunomodulatory treatment can be helpful in some cases, but limited data is available.
objectivesCompare the effects of symptomatic treatments alone, an immunosuppressive dosage of prednisolone, or modified cyclosporine on serum feline pancreatic lipase immunoreactivity (fPLI) concentration and clinical activity index (CAI). ANIMALS: Forty-eight client-owned cats with a presumptive diagnosis of chronic pancreatitis were managed on an outpatient basis.
methodsThree-week randomized open-label trial with a nonrandomized active control. Owners elected to join either the control or the treatment group; cats enrolled in the treatment group were randomized to receive either prednisolone or cyclosporine. Serum fPLI concentration and clinical signs were recorded at baseline and on Days 10 and 21.
resultsThe average decrease in serum fPLI concentration was 13.0 μg/L (95% CI, -23.9 to -0.9 μg/L) larger for the cyclosporine group (n = 17) than for the control group (n = 16) and 27.6 μg/L (95% CI, -41.2 to -11.4 μg/L) larger than for the prednisolone group (n = 15). The average decrease in CAI was 1.9 points (95% CI, -2.7 to -1.2) larger for the prednisolone group than for the control group and 1.2 points (95% CI, -2.1 to -0.4) larger than for the cyclosporine group.
conclusionsOver a 3-week treatment period, cats with presumed chronic pancreatitis that received cyclosporine had a larger decrease in serum fPLI concentration compared with cats that were treated with an immunosuppressive dosage of prednisolone or cats that received only symptomatic treatments. However, clinical improvement was more apparent with prednisolone, but not cyclosporine.
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