Evidence map›Paper›PMID 40577169›Full record

ArticleACS chemical biology2025

Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses.

Hyun Bong Park, Deguang Song, Mytien Nguyen, Noah W Palm, Jason M Crawford

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyun Bong ParkDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-2986-3833
Deguang SongDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06536, United States.
Mytien NguyenDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06536, United States.
Noah W PalmDepartment of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06536, United States.
Jason M CrawfordDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-7583-1242

Funding

Microbial Chemical Sensing and Host ResponsesRM1GM141649 · NIGMS · YALE UNIVERSITY · PI Jason Michael Crawford, Caroline Helen Johnson · 2021 to 2026
$9.0M
A forward chemical genetic screen to illuminate the dark matter of the bioactive microbiota metabolomeDP2DK125119 · NIDDK · YALE UNIVERSITY · PI PALM, NOAH WOLCOTT · 2019 to 2019
$2.5M
NIDDK NIH HHS DP2 DK125119NIGMS NIH HHS RM1 GM141649
6 · The paper itself

Abstract

Gut microbes secrete specialized small molecules that broadly influence human physiology. Despite their potential significance, the variety of functional small molecules known in the gut is relatively limited. Here, we screened the supernatants from human fecal-derived bacterial cultures to explore their agonist effects on the human G protein-coupled receptors (GPCRs), melatonin receptor types 1A and 1B (MTNR1A, MTNR1B). Chemical analysis of the supernatant-soluble molecules of

Indexed as

ClostridiumGastrointestinal MicrobiomeSignal TransductionTryptaminesAnimalsHumansMiceReceptors, G-Protein-CoupledReceptors, G-Protein-CoupledtryptamineTryptamines

Identifiers

PMID40577169
PMCPMC12372651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.