Evidence map›Paper›PMID 40577131›Full record

ArticleCell reports2025

Quantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming.

Patricia Favaro, David R Glass, Luciene Borges, Reema Baskar, Avery Lam, Warren Reynolds, Daniel Ho, Trevor Bruce, Dmitry Tebaykin, Thomas Koehnke and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Patricia FavaroDepartment of Pathology, Stanford University, Stanford, CA, USA.
David R GlassDepartment of Pathology, Stanford University, Stanford, CA, USA; Immunology Graduate Program, Stanford University, Palo Alto, CA, USA.
Luciene BorgesDepartment of Pathology, Stanford University, Stanford, CA, USA.
Reema BaskarDepartment of Pathology, Stanford University, Stanford, CA, USA.
Avery LamDepartment of Pathology, Stanford University, Stanford, CA, USA.
Warren ReynoldsDepartment of Pathology, Stanford University, Stanford, CA, USA; Immunology Graduate Program, Stanford University, Palo Alto, CA, USA.
Daniel HoDepartment of Pathology, Stanford University, Stanford, CA, USA.
Trevor BruceDepartment of Pathology, Stanford University, Stanford, CA, USA.
Dmitry TebaykinDepartment of Pathology, Stanford University, Stanford, CA, USA.
Thomas KoehnkeDepartment of Medicine, Division of Hematology, Stanford University, Stanford, CA, USA.
Vanessa M ScanlonDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Ilya Shestopalovbluebird bio, Somerville, MA 02145, USA.
Sean C BendallDepartment of Pathology, Stanford University, Stanford, CA, USA; Immunology Graduate Program, Stanford University, Palo Alto, CA, USA. Electronic address: bendall@stanford.edu.

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Inma Cobos · 2020 to 2026
$29.0M
Stanford Cancer Immune Monitoring and Analysis Center (CIMAC)U24CA224309 · NCI · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Holden T. Maecker · 2017 to 2026
$19.9M
Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI TIAN, LU · 2020 to 2024
$15.9M
The Bone Marrow Multi-modal Imaging CoreU54HL165445 · NHLBI · STANFORD UNIVERSITY · PI ANGELO, ROBERT MICHAEL, BENDALL, SEAN CURTIS · 2022 to 2025
$5.9M
MIRIAD - Multiplexed Imaging of Resilience In Alzheimers DiseaseR01AG057915 · NIA · STANFORD UNIVERSITY · PI ANGELO, ROBERT MICHAEL, BENDALL, SEAN CURTIS · 2017 to 2021
$4.5M
The Phenotypic Landscape of Cognitive Decline as Revealed by Next-Generation Multiplexed Ion Beam ImagingR01AG056287 · NIA · STANFORD UNIVERSITY · PI ANGELO, ROBERT MICHAEL, BENDALL, SEAN CURTIS · 2017 to 2021
$2.6M
Origins of human blood lineages in regenerative medicineDP2EB024246 · NIBIB · STANFORD UNIVERSITY · PI BENDALL, SEAN CURTIS · 2016 to 2016
$2.4M
Uncoupling Age- Versus Cognitive-Related Cellular Senescence in Alzheimer's DiseaseR01AG068279 · NIA · STANFORD UNIVERSITY · PI BENDALL, SEAN CURTIS · 2020 to 2024
$1.9M
NCI NIH HHS U24 CA224309NHLBI NIH HHS U54 HL165445NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG056287NIA NIH HHS R01 AG057915NIA NIH HHS R01 AG068279NIA NIH HHS U19 AG065156NIBIB NIH HHS DP2 EB024246
6 · The paper itself

Abstract

Hematopoietic stem and progenitor cell (HSPC) transplantation is an essential therapy for hematological conditions, but finer definitions of human HSPC subsets with associated function could enable better tuning of grafts and more routine, lower-risk application. To deeply phenotype HSPCs, following a screen of 328 antigens, we quantified 41 surface proteins and functional regulators on millions of CD34

Indexed as

Cell LineageErythroid CellsHematopoietic Stem CellsAnimalsAntigens, CD34Cell DifferentiationFetal BloodHumansAntigens, CD34ATAC-sequencingCP: Developmental biologyerythrocyte/megakaryocyte lineagehematopoietic stem and progenitor cellhuman hematopoiesisin vivo lineage tracingmass cytometrymolecular regulatorsingle celltrajectory analysistranscription factor

Identifiers

PMID40577131
PMCPMC13134577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.