Evidence map›Paper›PMID 40577074›Full record

ArticleJournal of studies on alcohol and drugs2025

Polygenic Risk for Substance Use Disorders as Predictors of Substance Use Initiation Among African American Youth.

David W Sosnowski, Jill A Rabinowitz, Kenneth A Feder, Justin C Strickland, Dana B Hancock, George R Uhl, Nicholas S Ialongo, Brion S Maher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of studies on alcohol and drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David W SosnowskiDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Jill A RabinowitzDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey.
Kenneth A FederDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Justin C StricklandDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.
Dana B HancockRTI International, Research Triangle Park, North Carolina.
George R UhlDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Nicholas S IalongoDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Brion S MaherDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Funding

PERIODIC FOLLOW UP OF TWO UNIVERSAL PREVENTIVE TRIALSR01MH057005 · NIMH · JOHNS HOPKINS UNIVERSITY · PI IALONGO, NICHOLAS S · 1998 to 2007
$4.2M
Development &Malleability from Childhood to AdulthoodR37DA011796 · NIDA · JOHNS HOPKINS UNIVERSITY · PI IALONGO, NICHOLAS S · 2005 to 2013
$3.6M
FOLLOWUP OF TWO UNIVERSAL PREVENTIVE INTERVENTIONSR01DA011796 · NIDA · JOHNS HOPKINS UNIVERSITY · PI IALONGO, NICHOLAS S · 1999 to 2004
$2.0M
Genes, Environment and Drug Use in Three Baltimore CohortsR01DA036525 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MAHER, BRION S · 2015 to 2017
$727k
NIDA NIH HHS R01 DA011796NIDA NIH HHS R01 DA036525NIDA NIH HHS R37 DA011796NIMHD NIH HHS L60 MD017785NIMH NIH HHS R01 MH057005
6 · The paper itself

Abstract

objectiveDespite adverse health consequences associated with early substance use initiation, less is known about the influence of genetic risk on initiation and environmental characteristics that may moderate these associations, particularly among African Americans. We examined whether genetic risk for alcohol use disorder, cannabis use disorder, and nicotine dependence is associated with age at initiation of these substances and whether community disadvantage and parental monitoring moderate these associations in a sample of African American youth.

methodParticipants (

resultsHigher alcohol use disorder polygenic risk scores (PRSs) were associated with later alcohol initiation (hazard ratio = 0.78, 95% CI [0.65, 0.94]). Cannabis use disorder and nicotine dependence PRSs were not associated with initiation of these substances. We observed an interaction between the cannabis use disorder PRS and parental monitoring; among individuals with high cannabis use disorder PRS, high monitoring was associated with earlier cannabis initiation, whereas among individuals with low PRS, low monitoring was associated with earlier initiation.

conclusionsFindings largely indicate that PRSs for substance use disorders are not associated with age at initiation among African American youth. Parental monitoring may influence the association between cannabis use disorder PRS and age at cannabis initiation, but replication of our findings is warranted.

Indexed as

Black or African AmericanMultifactorial InheritanceSubstance-Related DisordersAdolescentChildFemaleGenetic Predisposition to DiseaseHumansMaleMarijuana AbuseRisk FactorsTobacco Use DisorderWhiteYoung Adult

Identifiers

PMID40577074
PMCPMC12315097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.