Evidence map›Paper›PMID 40577028›Full record

ArticleFuture medicinal chemistry2025

Synthesis and docking of new Schiff-bases bearing urea as promising dual α-amylase and α-glucosidase inhibitors.

Sarah S Alammari, Fahd M Alminderej, Sabri Messaoudi, Haja Tar, Hamdoon A Mohammed, Suliman A Almahmoud, Ruba Al-Nemi, Mariusz Jaremko, Abdul-Hamid Emwas, Lotfi M Aroua

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Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah S AlammariDepartment of Chemistry, College of Science, Qassim University, Buraydah, Kingdom of Saudi Arabia.
Fahd M AlminderejDepartment of Chemistry, College of Science, Qassim University, Buraydah, Kingdom of Saudi Arabia.
Sabri MessaoudiDepartment of Chemistry, College of Science, Qassim University, Buraydah, Kingdom of Saudi Arabia.
Haja TarDepartment of Chemistry, College of Science, Qassim University, Buraydah, Kingdom of Saudi Arabia.
Hamdoon A MohammedDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Kingdom of Saudi Arabia.
Suliman A AlmahmoudDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Kingdom of Saudi Arabia.
Ruba Al-NemiBioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Mariusz JaremkoBioscience Program, Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Abdul-Hamid EmwasCore Laboratories, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Lotfi M ArouaDepartment of Chemistry, College of Science, Qassim University, Buraydah, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo synthesise and evaluate new amino biaryl-urea ( MATERIALS AND

methodsA series of Schiff base urea derivatives were synthesised through a two-step procedure: condensation of 4-chloro-o-phenylenediamine with isocyanates to form amino biaryl-urea derivatives (

resultsDerivatives

conclusionsThe di-fluoro and di-chloro substituents in compounds

Indexed as

alpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsUreaHumansMolecular Docking SimulationMolecular StructureSchiff BasesStructure-Activity Relationshipalpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsSchiff BasesUreamolecular dockingmolecular dynamicsSchiff baseSynthesisα-amylaseα-glucosidase

Identifiers

PMID40577028
PMCPMC12296107

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.