Evidence map›Paper›PMID 40576910›Full record

ArticleGeroScience2026

Deep learning predicts onset acceleration of 38 age-associated diseases from blood and body composition biomarkers in the UK Biobank.

Mica Xu Ji, Marjola Thanaj, Léna Nehale-Ezzine, Brandon Whitcher, E Louise Thomas, Jimmy D Bell

Abstract read
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mica Xu JiResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK. m.ji1@westminster.ac.uk.ORCID 0000-0001-6769-6944
Marjola ThanajResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
Léna Nehale-EzzineMila - Quebec AI Institute, Montreal, Canada.
Brandon WhitcherResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
E Louise ThomasResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
Jimmy D BellResearch Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major challenge in multimorbid aging is understanding how diseases co-occur and identifying high-risk groups for accelerated disease development, but to date associations in the relative onset acceleration of disease diagnoses have not been used to characterize disease patterns. This study presents the development and evaluation of a neural network Cox model for predicting onset acceleration risk for age-associated conditions, using demographic, anthropomorphic, imaging, and blood biomarker traits from 60,396 individuals and 218,530 outcome events from the UK Biobank. Risk prediction was evaluated with Harrell's concordance index (C-index). The model performed well on internal (C-index

Indexed as

AgingBody CompositionDeep LearningAgedAged, 80 and overBiological Specimen BanksBiomarkersFemaleHumansMaleMiddle AgedProportional Hazards ModelsRisk AssessmentRisk FactorsUK BiobankUnited KingdomBiomarkersDeep learningHealthy agingMultimorbidityUK Biobank

Identifiers

PMID40576910
PMCPMC12972428

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.