ArticleLa Radiologia medica2025
Assessment of hypothalamic macrostructure in episodic cluster headache: a volumetric segmentation MRI study.
Article in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- White matter microstructural alterations in episodic cluster headache outside attacks: a tract-based spatial statistics study.The journal of headache and pain · 2026Article
- Multimodal MRI of episodic cluster headache reveals frontal cortical alterations and network-level connectivity changes.The journal of headache and pain · 2026Article
- Hallmarks of primary headache: part 4 - rare headache syndromes.The journal of headache and pain · 2025Review
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Authors and funding
10 authors.
Funding
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Abstract
purposeThe functional involvement of the hypothalamus in the pathophysiology of episodic cluster headache (eCH) is well known, but its macrostructural involvement remains unclear. In this study, we investigated differences in the volumetry of the entire hypothalamus and its subunits in patients with in-bout eCH during headache-free periods. MATERIAL AND
methodsWe examined hypothalamic volumes in 26 eCH patients (scanned during bout periods but outside of active attacks and off prophylactic medications) and 20 age- and sex-matched healthy controls (HCs). Magnetic resonance imaging (MRI) with T1-weighted sequences was used to perform volumetric segmentation of hypothalamic subunits (anterior-inferior, anterior-superior, posterior, tubular inferior, and tubular superior) and total hypothalamic volume. General linear models were used to assess volumetric differences, adjusting for age, sex, and total intracranial volume.
resultsNo statistically significant differences were found in either hypothalamic subunit volumes or total hypothalamic volumes between eCH patients and HCs (p > 0.05). Additionally, no correlations emerged between the hypothalamic volumes and CH clinical features.
conclusionThese findings align with previous studies, suggesting that CH pathophysiology may involve network-level functional alterations rather than macrostructural hypothalamic changes.
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