Evidence map›Paper›PMID 40576864›Full record

ArticleBreast cancer research and treatment2025

The use of indocyanine green and technetium-99 for dual-tracer sentinel lymph node biopsy in breast cancer.

Madison Kolbow, Qianyun Luo, Alicia Cerrato Grande, Schelomo Marmor, Jennifer Witt, Sydne Muratore, Todd M Tuttle, Jane Y C Hui

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Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Madison KolbowUniversity of Minnesota Medical School, Minneapolis, MN, USA.
Qianyun LuoUniversity of Minnesota Medical School, Minneapolis, MN, USA.
Alicia Cerrato GrandeBreast Department, Division of Surgical Oncology, La Liga Contra el Cáncer, San Pedro Sula, Honduras.
Schelomo MarmorDivision of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
Jennifer WittDepartment of Surgery, Minnesota Oncology, Minneapolis, MN, USA.
Sydne MuratoreDepartment of Surgery, Intermountain Health, Peaks Region, Denver, CO, USA.
Todd M TuttleDivision of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
Jane Y C HuiDivision of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA. jhui@umn.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to determine if indocyanine green (ICG) is a suitable replacement for blue dye for dual-tracer sentinel lymph node biopsy (SLNB).

methodsA single-center retrospective review of female breast cancer patients aged ≥ 18 years who underwent SLNB with technetium-99 (Tc

resultsOne hundred and nineteen SLNBs were performed on 117 patients. At least one radioactive or fluorescent SLN was identified in 93.2% of all patients. The mean number of SLNs retrieved per SLNB was 1.6 (fluorescent, 1.5; radioactive, 1.5). Of all excised SLNs, 89.4% were fluorescent, 88.4% were radioactive, and 81.9% were both fluorescent and radioactive. SLN metastases were present in 26 patients (22.2%); of SLNs identified with metastases on pathologic examination, 87.2% were fluorescent, 74.4% were radioactive, and 71.8% were both radioactive and fluorescent. Two patients (1.7%) experienced skin flap necrosis and one patient (0.9%) experienced prolonged skin discoloration. No patients experienced allergic reactions.

conclusionThis study demonstrates that SLN identification rates using ICG and Tc

Indexed as

Breast NeoplasmsIndocyanine GreenRadiopharmaceuticalsSentinel Lymph NodeSentinel Lymph Node BiopsyTechnetiumAdultAgedAged, 80 and overColoring AgentsFemaleHumansLymphatic MetastasisMiddle AgedRetrospective StudiesColoring AgentsIndocyanine GreenRadiopharmaceuticalsTechnetiumTechnetium-99Breast cancer surgeryIndocyanine greenSentinel lymph node biopsySentinel lymph node mapping

Identifiers

PMID40576864
PMCPMC12259722

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.