Trial reportInternational ophthalmology2025
Early combined conbercept and dexamethasone implant therapy for diabetic macular edema.
Trial report in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy and safety of ranibizumab, aflibercept, and conbercept in the treatment of diabetic macular edema: a retrospective comparative study.Scientific reports · 2026Article
- Recent advances in the study of Conbercept for diabetic macular edema.International journal of retina and vitreous · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study evaluated the clinical effectiveness and safety of a combined dexamethasone implant (Ozurdex) with Conbercept injections for diabetic macular edema (DME).
methodsA prospective case-control clinical trial was conducted on 46 DME patients. Patients were randomly assigned to either the combination group, receiving Conbercept injections followed by Ozurdex (24 patients) using a 2 + 1 + 1 + PRN protocol, or the monotherapy group, receiving only Conbercept injections (22 patients) following a 5 + PRN protocol. Monthly evaluations were performed at six and twelve months to compare best-corrected visual acuity (BCVA), central macular thickness (CMT), injection frequency, and safety outcomes such as endophthalmitis, cataract development, retinal detachment, and intraocular pressure elevation.
resultsResults showed that the combination group's 12-month BCVA improvement rate was 97.05%, significantly higher than the monotherapy group's 76.47% (P < 0.05). Both groups' BCVA and CMT significantly improved from baseline at six and twelve months (P < 0.05). CMT differences were significant (P < 0.05). The combination group received an average of 5.29 injections, compared to 8.15 in the monotherapy group. In terms of safety, 17.6% of eyes in the combination group had intraocular pressures ≥ 25 mmHg, managed with observation or topical therapy. At 12 months, 17.6% and 29.4% of eyes in the two groups underwent cataract surgery, respectively, with no cases of endophthalmitis or retinal detachment.
conclusionEarly combined therapy with dexamethasone implant (Ozurdex) and Conbercept injections offers significant clinical benefits for the treatment of DME during the initial three months of treatment.
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Registered trials
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