ArticleActa neurochirurgica2025
Socioeconomic influences on survival outcome in idh-wildtype glioma patients: examining the role of age, education, and lifestyle factors.
Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Actin, connexin-43 and GAP-43 expression in gliomas: real-world associations with IDH status, tumor burden and survival.Journal of neuro-oncology · 2026Article
- Review of glioblastoma and systemic comorbidities.Frontiers in oncology · 2026Review
- Prognostic modeling for diffuse midline glioma: development and validation of a risk stratification nomogram using SEER and institutional cohorts.Frontiers in oncology · 2025Article
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6 authors.
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Abstract
backgroundSocioeconomic factors influence survival in different cancer types. This study aimed to assess the impact of various socioeconomic factors, including education, marital status, lifestyle, and social network, on survival in patients with Isocitrate dehydrogenase (IDH) wildtype gliomas.
methodsWe conducted a retrospective analysis of 309 adult patients with de novo diagnosed IDH wildtype gliomas who underwent surgical treatment at our institution between 2014 and 2022. Socioeconomic factors, including education, marital status, employment, language, lifestyle (alcohol abuse, smoking, BMI), and social network were assessed. Progression-free survival (PFS) and overall survival (OS) were analyzed using Kaplan-Meier and Cox regression models.
resultsEducation, alcohol abuse, and age significantly influenced OS. Patients with higher education had significantly lower tumor volumes (p = 0.037) and longer survival (p = 0.001). Alcohol abuse was associated with significantly shorter OS (8.6 vs. 17.9 months, p = 0.034). Patients aged over 65 years showed significantly shorter OS in this study (14.9 months vs 33.2 months, p < 0.001). Native and non-native German speakers had similar outcomes. Marital status did not significantly affect survival.
conclusionSocioeconomic and lifestyle factors, especially higher education and alcohol abuse, significantly impact survival in IDH wildtype glioma patients. These findings suggest that, in addition to molecular features and oncological treatment, socioeconomic and lifestyle factors also play a crucial role in influencing the prognosis of patients with IDH wildtype gliomas.
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