ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025
Determination of SCUBE-1, SCUBE-2, caveolin-1, and ischemia biomarker levels in rats following renal ischemia-reperfusion.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the histopathological findings and serum levels of ischemia and oxidative stress biomarkers in a rat model of renal ischemia-reperfusion injury.
methodsFifty-one female Wistar rats were randomly allocated into six groups: ischemia/third day, ischemia/first week, ischemia/second week, and corresponding control groups for each ischemia group. Each ischemia group had 10 rats, and each control group had seven. Ischemia was induced by clamping the left renal hilum for 45 min, followed by reperfusion. Relaparotomy was performed at designated time points, and blood and kidney samples were collected. Control groups underwent laparotomy without ischemia. Serum levels of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor-like domain-containing protein 1 and 2 (SCUBE-1/2), caveolin-1 (Cav-1), albumin, ischemia-modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), IMA/albumin ratio (IMAR), creatinine, and blood urea nitrogen were analyzed, and histopathological examinations were undertaken.
resultsIn the ischemia groups, serum levels of SCUBE-1, IMA, TAS, TOS, creatinine, IMAR, and OSI statistically significantly differed from those in the control groups. Serum Cav-1 levels showed a statistically significant difference between the third-day and first-week groups, whereas no statistically significant difference was observed between the ischemia and control groups in the second-week cohort.
conclusionSignificant differences in ischemia and oxidative stress biomarkers, including SCUBE-1 and Cav-1, were observed. SCUBE-1 and Cav-1 may serve as potential biomarkers for assessing kidney injury, function, and recovery.
Indexed as
Identifiers
40576786What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.