Evidence map›Paper›PMID 40576735›Full record

ArticleAnnals of nuclear medicine2025

Prognostic significance of non-perfusion parameters of cadmium-zinc-telluride single-photon emission computed tomography myocardial perfusion imaging for individuals with normal myocardial perfusion: a large-scale single-center retrospective cohort study.

Chih-Yi Lin, Li-Hua Tang, Yi-Hsien Chou, Chi-Lun Ko, Mei-Fang Cheng, Chien-Jung Chen, Kuan-Yin Ko, Chia-Ju Liu

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Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Chih-Yi LinDepartment of Nuclear Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan.
Li-Hua TangDepartment of Nuclear Medicine, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei, 100225, Taiwan.
Yi-Hsien ChouDepartment of Nuclear Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan.
Chi-Lun KoDepartment of Nuclear Medicine, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei, 100225, Taiwan.
Mei-Fang ChengDepartment of Nuclear Medicine, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei, 100225, Taiwan.
Chien-Jung ChenDepartment of Nuclear Medicine, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei, 100225, Taiwan.
Kuan-Yin Ko *Department of Nuclear Medicine, National Taiwan University Cancer Center, No. 57, Ln. 155, Sec. 3, Keelung Rd., Da'an Dist., Taipei, 106037, Taiwan. Cindyko731228@gmail.com.
Chia-Ju Liu *Department of Nuclear Medicine, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei, 100225, Taiwan. cj_liu@ntuh.gov.tw.ORCID http://orcid.org/0000-0003-1641-5617

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe study aimed to assess the prognostic value of non-perfusion parameters for gated myocardial perfusion imaging (MPI) performed using Cadmium-Zinc-Telluride (CZT) single-photon emission computed tomography (SPECT) for individuals with normal myocardial perfusion.

methodsWe analyzed data from consecutive patients who underwent thallium-201 MPI SPECT with normal perfusion. Major adverse cardiovascular events (MACEs) were recorded during a 2-year follow-up. Non-perfusion parameters were evaluated as predictors of MACEs.

resultsAmong 1570 patients with normal SPECT perfusion, 80 (5.1%) experienced MACEs over a mean follow-up of 22.5 ± 10.8 months: 12 (0.8%) had cardiac death, and 68 (4.3%) underwent coronary revascularization due to significant coronary artery disease. Independent predictors of MACEs included worsening post-stress ejection fraction (HR: 1.971; p = 0.008), and increased lung-to-heart ratio (HR: 2.207; p = 0.001). Kaplan-Meier analysis showed the highest MACEs' incidence in patients with two of these factors (p < 0.001). Among patients with normal resting ejection fraction, EF worsening (OR: 2.16; p = 0.004) and increased lung-to-heart ratio (OR: 1.91; p = 0.0013) both remained strong predictors.

conclusionsAlthough normal myocardial perfusion typically indicates low risk for obstructive coronary artery disease, worsening post-stress ejection fraction and increased lung-to-heart ratio are crucial prognostic indicators. Importantly, these non-perfusion parameters retain their prognostic value even in patients without clinical heart failure, highlighting their relevance in comprehensive risk stratification beyond perfusion assessment alone.

Indexed as

CadmiumMyocardial Perfusion ImagingTelluriumTomography, Emission-Computed, Single-PhotonZincAgedCoronary Artery DiseaseFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesCadmiumCdZnTeTelluriumZincCadmium Zinc Telluride (CZT)Major adverse cardiovascular events (MACEs)Non-perfusion parametersPost-stress ejection fractionSingle photon emission computed tomography (SPECT)

Identifiers

PMID40576735

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