ArticleVirchows Archiv : an international journal of pathology2026
Low heterogeneity of tumor grades in multiple MRI-targeted prostate biopsies argues for the aggregate method of grading.
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer diagnosis primarily relies on histological confirmation via needle core biopsy, with systematic 12-core biopsies (SB) being commonly used. Multiparametric magnetic resonance imaging (mpMRI) and MRI-targeted biopsies have shown enhanced detection of clinically significant prostate cancer. This study compares two tumor grading methods-aggregate and individual grading-used in MRI-targeted biopsies to assess their correlation with the final ISUP Grade Group (GG) of the RPE. A cohort of 108 patients with ≥ 2 positive cores in at least one MRI-targeted biopsy, totaling 179 positive lesions, was analyzed. Systematic and MRI-targeted biopsies were correlated with RPE specimens. The mean highest ISUP GG for systematic biopsies was 2.77 (SD ± 1.29), compared to 2.62 (SD ± 1.13) for targeted biopsies using the aggregate method. Comparing the highest ISUP GG in systematic as well as targeted biopsies with the final ISUP GG of the RPE, exact correlation between GG was found in 70.1% (aggregate) and 66.4% (individual) for targeted biopsies and 58.1% for systematic biopsies. The results of the individual method showed slightly better correlation with the final ISUP GG from the RPE specimen in only 0.93%, while in 2.8% of cases, it resulted in inferior correlation compared to the aggregate method. Our findings suggest that the aggregate grading method of targeted biopsies is preferable due to its comparable predictive accuracy, lower workload, and alignment with existing clinical guidelines. This supports the ISUP's recommendation to use the aggregate method for MRI-targeted biopsies in clinical practice. Further research is needed to standardize reporting protocols for MRI-targeted biopsies and refine their integration into prostate cancer risk stratification models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.