Evidence map›Paper›PMID 40576700›Full record

ArticleNeurochemical research2025

Piper Kadsura Extract and its Bioactive Components Attenuates Aβ

Kaili Ye, Mengnan Zeng, Beibei Zhang, Fengxiao Hao, Pengli Guo, Yuhan Zhang, Tong Liu, Hui Chen, Weisheng Feng, Xiaoke Zheng

Abstract read
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In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kaili YeSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Mengnan ZengSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Beibei ZhangSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Fengxiao HaoSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Pengli GuoSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Yuhan ZhangSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Tong LiuThe Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, China.
Hui ChenSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Weisheng FengSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Xiaoke ZhengSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China. zhengxk.2006@163.com.

Funding

Henan Science and Technology Research and Development Plan Joint Fund 242301420082National Key Research and Development Project 2017YFC1702800National Key Research and Development Project 2019YFC1708802Program for Innovative Research Team (in Science and Technology) in University of Henan Province 24IRTSTHN039the National Natural Science Foundation of China 32200322
6 · The paper itself

Abstract

Piper kadsura (Choisy) Ohwi, a traditional medicinal plant used in East Asia, is renowned for its anti-inflammatory and antioxidant properties. Its bioactive components, such as Hancinone and Futoquinol, show potential in treating neurodegenerative disorders like Alzheimer's disease (AD). Aim of the study: This study investigates the neuroprotective effects of Piper kadsura extract (PK) and its active components, Hancinone (C1) and Futoquinol (C2), in Aβ

Indexed as

Amyloid beta-PeptidesGlycolysisNeuroprotective AgentsPeptide FragmentsPiperPlant ExtractsAlzheimer DiseaseAnimalsCell SurvivalGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLMolecular Docking SimulationOxidative StressPC12 CellsAmyloid beta-Peptidesamyloid beta-protein (25-35)Neuroprotective AgentsPeptide FragmentsPlant ExtractsPPAR gammaSirt1 protein, mouseSirtuin 1GlycolysisNeurotoxicityPiper kadsura, Alzheimer’s diseaseSIRT1/PPARγ/GLUT1

Identifiers

PMID40576700

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.