Evidence map›Paper›PMID 40576686›Full record

ArticleAnnals of hematology2025

Effectiveness of venetoclax based therapy in t(11;14) multiple myeloma with extensive extramedullary disease: a case report.

Kerstin Brinkert, Bernd Heinrich, Annamaria Brioli, Michael Heuser, Hans Heinrich Kreipe, Florian H Heidel, Arnold Ganser, Gernot Beutel

Abstract readCase Reports
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kerstin BrinkertDepartment of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, 30625, Germany. Brinkert.kerstin@mh-hannover.de.
Bernd HeinrichDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Annamaria BrioliDepartment of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, 30625, Germany.
Michael HeuserDepartment of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, 30625, Germany.
Hans Heinrich KreipeInstitute of Pathology, Hannover Medical School, Hannover, Germany.
Florian H HeidelDepartment of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, 30625, Germany.
Arnold GanserDepartment of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, 30625, Germany.
Gernot BeutelDepartment of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, 30625, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extramedullary disease in patients with newly diagnosed multiple myeloma is rare and, despite the abundance of new therapeutic options, is still associated with a dismal prognosis, classifying as an unmet clinical need. Here, we report the case of a young woman diagnosed with multiple myeloma and extensive extramedullary disease characterised by diffuse lymph node involvement. The patient received multiple chemotherapy regimens proving to be refractory to all of them and ultimately benefited from salvage therapy with Venetoclax combination therapy, with a complete disappearance of the extramedullary manifestations. This case proves the effectiveness of Venetoclax in t(11;14) myeloma with extramedullary involvement.

Indexed as

Bridged Bicyclo Compounds, HeterocyclicChromosomes, Human, Pair 11Chromosomes, Human, Pair 14Multiple MyelomaSulfonamidesTranslocation, GeneticAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansTreatment OutcomeYoung AdultBridged Bicyclo Compounds, HeterocyclicSulfonamidesvenetoclaxExtramedullary myelomat (11;14)Target therapyVenetoclax

Identifiers

PMID40576686
PMCPMC12432085

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.