Evidence map›Paper›PMID 40576654›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025

Obesity influences the biological response to injury: a multi-omics analysis.

Terry R Schaid, Christopher Erickson, Angelo D'Alessandro, Kirk Hansen, Otto Thielen, William Hallas, Lauren Gallagher, Alexis Cralley, Ian LaCroix, Benjamin Ramser and 6 more

Abstract read
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In one paragraph

Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Terry R SchaidSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA. terry.schaid@cuanschutz.edu.
Christopher EricksonSchool of Medicine, Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, USA.
Angelo D'AlessandroSchool of Medicine, Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, USA.
Kirk HansenSchool of Medicine, Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, USA.
Otto ThielenSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
William HallasSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
Lauren GallagherSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
Alexis CralleySchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
Ian LaCroixSchool of Medicine, Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, USA.
Benjamin RamserSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
Benjamin StockerSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
Sanchayita MitraSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
Preston StaffordSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
Monica DzieciatkowskaSchool of Medicine, Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, USA.
Christopher SillimanSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.
Mitchell CohenSchool of Medicine, Department of Surgery, University of Colorado Denver, Trauma Research Center, Aurora, CO, USA.

Funding

Mechanisms of Trauma-Induced CoagulopathyT32GM008315 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Mitchell Cohen, ELIZABETH J. KOVACS · 1991 to 2026
$7.1M
NIGMS NIH HHS T32 GM008315NIH HHS 1RM1GM131968-01Trans-agency Research Consortium for Trauma Induced Coagulopathy from the National Heart, Lung and Blood Institute, NIH TACTIC UM1-HL120877
6 · The paper itself

Abstract

purposeObesity is a prevalent disease, but its influence on post-injury biology remains unclear. In this study, we aimed to characterize the independent effect of obesity on the proteomic and metabolomic signatures of trauma.

methodsPlasma was obtained on arrival from injured patients at a Level 1 Trauma Center and analyzed with modern mass spectrometry-based proteomics and metabolomics. Samples obtained after start of transfusion were excluded. Patients were stratified by "obesity" (body mass index [BMI]≥30 kg/m

resultsThere were 183 patients included (48 [26%] with obesity and 135 [74%] without). After covariate-adjustment, multiple proteins and metabolites were correlated with ISS and/or BE and were significantly different from Low Injury/Low Shock to High Injury/High Shock only in patients with obesity. This obesity-specific omics response to injury was characterized by increased inflammation, hypercoagulability, altered nitrogen metabolism, and mitochondrial dysfunction. Patients with obesity also exhibited excessive injury-provoked tissue destruction and organ damage compared to patients without obesity. In injury severity-adjusted analyses, the obesity signature consistently displayed markers of hemolysis, likely reflecting a pre-injury hemolytic propensity.

conclusionObesity is independently associated with altered post-injury biology, which likely underlies unique pathology in trauma patients with obesity. Identifying this aberrant response to injury is the first step in developing personalized therapies for this patient population.

Indexed as

ObesityWounds and InjuriesAdultBody Mass IndexFemaleHumansInflammationInjury Severity ScoreMaleMetabolomicsMiddle AgedMultiomicsProteomicsInjuryMetabolomicsObesityProteomicsTrauma

Identifiers

PMID40576654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.