Evidence map›Paper›PMID 40576594›Full record

ArticleJACC. Case reports2025

Transcatheter Treatment of Patient With Mitral Valve Endocarditis and Severe Aortic Stenosis and Insufficiency.

Dhiren R Rajagopal, Rishab Jayanthi, Jennifer J Bolivar Aldana, James P Stewart, Hassan S Sayegh, Peter B Flueckiger, Sara Mobasseri, Mark R Helmers, Vinod H Thourani, Pradeep K Yadav

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Transcatheter Retrieval of Mitral Bioprosthetic Valve Vegetation With Extended Embolic Protection: A Case Report.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dhiren R RajagopalMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA; Georgia Institute of Technology, Atlanta, Georgia, USA.
Rishab JayanthiMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.
Jennifer J Bolivar AldanaMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.
James P StewartMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.
Hassan S SayeghMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.
Peter B FlueckigerMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.
Sara MobasseriMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.
Mark R HelmersMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.
Vinod H ThouraniMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA.
Pradeep K YadavMarcus Heart Valve Center, Piedmont Heart Institute, Atlanta, Georgia, USA. Electronic address: pradeep.yadav@piedmont.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients in cardiogenic shock secondary to endocarditis and multivalvular heart disease have a high surgical risk. Transcatheter valve aspiration followed by transcatheter valve intervention might be a strategy to salvage carefully selected patients. CASE SUMMARY: A 63-year-old woman with subaortic membrane and severe aortic stenosis/regurgitation was scheduled for membrane resection, aortic root enlargement, and aortic valve replacement. Two weeks before operation, she developed mitral valve endocarditis. Because of cardiogenic shock, she was placed on venoarterial extracorporeal membrane oxygenation with a left atrial vent. Transcatheter aspiration of mitral vegetation resulted in minimal residual valve pathology with culture clearance; the patient received transcatheter aortic valve replacement and was discharged to a rehabilitation facility. DISCUSSION: Surgery in patients with multivalvular disease with endocarditis and cardiogenic shock can be very high risk. Transcatheter aspiration of endocarditis and treatment of valvular disease might be an alternative to high-risk surgical therapy. TAKE-HOME MESSAGES: Surgical treatment has been the only available option for patients with endocarditis and multivalvular disease. In these patients at very high operative risk and with appropriate valvular anatomy, transcatheter aspiration of endocarditis followed by transcatheter therapy of multiple valvular lesions can be feasible alternative.

Indexed as

cardiogenic shockendocarditispercutaneous mechanical aspirationsevere aortic insufficiencysubaortic membranetranscatheter aortic valve replacement

Identifiers

PMID40576594
PMCPMC12373495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.