ArticleJACC. Case reports2025
Platypnea-Orthodeoxia Syndrome Due to Patent Foramen Ovale: A Diagnostic and Therapeutic Challenge.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Persistent Hypoxia After Tricuspid Valve Replacement.JACC. Case reports · 2026Article
- Horizontal Heart Orientation as a Mechanistic Contributor to Platypnea-Orthodeoxia Syndrome in Patent Foramen Ovale.Clinical case reports · 2026Article
- Platypnea-Orthodeoxia Syndrome Revealing an Undiagnosed Patent Foramen Ovale: A Case Report.Cureus · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatypnea-orthodeoxia syndrome (POS) is a rare condition characterized by dyspnea and hypoxia exacerbated by an upright position. It is often associated with intracardiac or pulmonary shunting. CASE SUMMARY: An 82-year-old woman presented with increasing fatigue, dizziness, and worsening dyspnea on exertion for 1 month. She was hypoxic, requiring high-flow oxygen. Initial work-up, including imaging and right heart catheterization, revealed an aneurysmal interatrial septum with a right-to-left shunt through a patent foramen ovale (PFO). The patient underwent successful percutaneous closure of the PFO, resulting in resolution of hypoxia and dyspnea. DISCUSSION: POS should be suspected in cases of positional hypoxia. The pathophysiology involves anatomical and hemodynamic factors that promote right-to-left shunting in specific positions. PFO closure is the definitive treatment, leading to symptom resolution. TAKE-HOME MESSAGES: POS should be considered in patients with unexplained positional hypoxia. PFO closure can significantly improve symptoms and quality of life in affected patients.
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