Evidence map›Paper›PMID 40576475›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2025

Is first-pass effect a meaningful metric to evaluate thrombectomy technologies?

Arjun Agrawal, Akash S Agrawal, Jase L Howell, Sevin B Barringer-Hoonhout, James D Fleck, Jason S Mackey, Andrew J DeNardo, Daniel P Gibson, Krishna Amuluru, Yasir Saleem and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Arjun AgrawalDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Akash S AgrawalDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Jase L HowellDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Sevin B Barringer-HoonhoutDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
James D FleckDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Jason S MackeyDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Andrew J DeNardoDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Daniel P GibsonDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Krishna AmuluruDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Yasir SaleemDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Charles G KulwinDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Troy D PaynerDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
Kushal J ShahDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.
J MoccoDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel H SahleinDepartment of Interventional Neuroradiology, Goodman Campbell Brain and Spine, Ascension St Vincent Hospital, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundGood clinical outcomes following stroke thrombectomy have been associated with successful reperfusion following a single pass, often referred to as the first pass effect (FPE). Inherent in FPE is a potential association with rapid recanalization. It remains unclear if the benefit associated with FPE is an epiphenomenon rather than a meaningful metric to evaluate thrombectomy. We retrospectively analyzed a high-volume single-practice database to evaluate the association of FPE with good clinical outcome.MethodsA database of 1047 consecutive thrombectomies from 2011 to 2020 was retrospectively queried. Demographics and presentation/procedural metrics were correlated with clinical outcome (3-month modified Rankin Scale (mRS)); patients aged 18 years and older with 3-month clinical follow-ups were included. Univariate analysis was performed to evaluate for an association with good clinical outcome (mRS 0-2) at 90 days. Variables meeting a univariate analysis

Indexed as

First-pass effectstroke thrombectomyvessel

Identifiers

PMID40576475
PMCPMC12204982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.