ArticleSocial cognitive and affective neuroscience2025
How do negative symptoms and social cognitive impairments overlap? Clustering analyses on patients living with schizophrenia-spectrum disorder.
Article in Social cognitive and affective neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Facial emotion recognition, insight and social functioning in first episode psychosis: a cross-sectional study from an observational cohort.BMC psychiatry · 2026Observational
- Digital psychoeducational rehabilitation supported by serious games for psychiatric inpatients: a protocol study.Frontiers in psychology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Negative symptoms and social cognition (SC) are intertwined in schizophrenia spectrum disorders (SSD), but the structure of this interaction is not yet fully understood. We employed cluster analyses to advance our understanding of the relationship between negative symptom severity and SC. We sought to identify discrete groups of patients as a function of two factors of negative symptoms-Motivation and Pleasure (MAP) and Expressivity (EXP)-and two domains of SC: emotion recognition (ER) and theory of mind (ToM). We conducted two cluster analyses to determine data-driven subgroups using two independent samples of SSD participants. The first was conducted with an open dataset (n = 296) and the second with a local sample (n = 138), to assess replicability. The first cluster analysis revealed a three-cluster solution. Both analyses highlighted distinct profiles: a 'Relatively Preserved' profile; a 'Combined Impairment' profile, with high negative symptoms and impaired ER and ToM; and a 'MAP' profile, with high MAP symptoms, some EXP symptoms, and slightly to moderately impaired ER and ToM. Reducing the heterogeneity in clinical presentations of SSD patients on these dimensions of negative symptoms and SC provides relevant information that could contribute to a more effective selection of interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.