ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2025
Complicated acute type A aortic dissection and severe aortic atherosclerosis predict early mortality after frozen elephant trunk procedure.
Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Frozen Elephant Trunk versus Ascyrus Medical Dissection Stent in Acute Type A Aortic Dissection: Choosing the Appropriate Arch Strategy.Aorta (Stamford, Conn.) · 2026Article
- Weighing the Risks: The Impact of Body Mass Index on Outcomes After Frozen Elephant Trunk Aortic Arch Repair.Medicina (Kaunas, Lithuania) · 2026Article
- In situ fenestration of a frozen elephant trunk prosthesis to recanalize the left subclavian artery.Journal of vascular surgery cases and innovative techniques · 2026Article
- Warming up the frozen elephant trunk for aortic arch pathology.Annals of cardiothoracic surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo analyse risk factors for early mortality and long-term survival including secondary distal aortic interventions in patients undergoing frozen elephant trunk surgery.
methodsA retrospective single-centre study was conducted, including all 222 patients who underwent frozen elephant trunk surgery between 2010 and 2022. We used multivariable regression analysis to detect risk factors for early mortality and Kaplan-Meier analysis for long-term survival and secondary interventions. We introduce the term 'complicated acute type A dissection' for those patients in whom the dissection was complicated by malperfusion syndrome, aortic rupture, pre-hospital intubation or resuscitation.
resultsThirty-day mortality decreased significantly from 18.9% using the conventional zone 3 technique to 7.4% using a simplified zone 2 technique (P = 0.014). The aortic pathology had a significant impact on 30-day mortality: 1.4% in chronic dissection, 6.7% in aortic aneurysm, 7.4% in noncomplicated acute type A aortic dissection and 42.5% in complicated acute type A aortic dissection (P < 0.001). We identified complicated acute type A aortic dissection [odds ratio 15.7, confidence interval (CI) 5.2-47.3, P < 0.001], severe aortic atherosclerosis (odds ratio 4.9, CI 1.6-15.3, P = 0.006) and impaired renal function (odds ratio 3.7, CI 1.1-12.4, P = 0.035) as independent predictors of early mortality. Among 30-day survivors, 5-year survival was 84.3%, with no differences between pathologies. Secondary distal aortic interventions (37.4%) did not affect 5-year survival (P = 0.909).
conclusionsEarly mortality after frozen elephant trunk surgery is strongly driven by preoperative patient condition, particularly in the presence of complicated acute type A dissection. Once the early postoperative phase is overcome, long-term outcome is favourable across pathologies, regardless of secondary interventions. Careful patient selection and regular follow-up are crucial for optimizing outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.