Evidence map›Paper›PMID 40576369›Full record

Observational studyActa paediatrica (Oslo, Norway : 1992)2025

Cerebral Oxygenation During Transition and Amplitude-Integrated Electroencephalography Signals: An Ancillary Study to the COSGOD-III Trial.

Christina Schreiner, Katharina Goeral, Marlene Hammerl, Katrin Klebermass-Schrehof, Alexander Avian, Vera Neubauer, Ursula Kiechl-Kohlendorfer, Daniel Pfurtscheller, Elke Griesmaier, Gerhard Pichler

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christina SchreinerDepartment of Paediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
Katharina GoeralDepartment of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care and Neuropaediatrics, Comprehensive Centre for Paediatrics, Medical University of Vienna, Vienna, Austria.
Marlene HammerlDepartment of Paediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
Katrin Klebermass-SchrehofDepartment of Paediatrics and Adolescent Medicine, Division of Neonatology, Paediatric Intensive Care and Neuropaediatrics, Comprehensive Centre for Paediatrics, Medical University of Vienna, Vienna, Austria.
Alexander AvianInstitute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.ORCID 0000-0003-1084-5763
Vera NeubauerDepartment of Paediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-6638-8624
Ursula Kiechl-KohlendorferDepartment of Paediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
Daniel PfurtschellerDivision of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
Elke GriesmaierDepartment of Paediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-9269-5756
Gerhard PichlerDivision of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.

Funding

Austrian Science Fund KLI615
6 · The paper itself

Abstract

aimThe COSGOD III trial was designed to guide oxygen delivery by cerebral near infrared spectroscopy (NIRS) in preterm neonates during the immediate transition after birth and showed a non-significant increase of 4.3% in survival without cerebral injury compared to the control group. This ancillary observational study investigated the effect of cerebral oximetry on electrocortical activity assessed by amplitude-integrated electroencephalography (aEEG).

methodsaEEG from three centres participating in the COSGOD III trial was evaluated for the total maturation score (TMS) and its four individual component scores, the visual background pattern and sleep-wake cycling.

resultsWe included 147 preterm infants with a mean gestational age of 28.1 weeks and a mean birth weight of 1020 g: 70 in the NIRS group, 77 in the control group. We found significantly higher total maturation scores, more mature sleep-wake cycles, and mature background patterns in the NIRS group compared to the control group.

conclusionIn the present cohort, NIRS-guided oxygen delivery combined with dedicated treatment guidelines during the immediate transition after birth showed an impact on electrocortical activity in the neonatal period. Whether this improvement in maturational aspects of the aEEG is also associated with better outcome needs to be evaluated in the long term.

Indexed as

BrainElectroencephalographyInfant, PrematureOxygenFemaleHumansInfant, NewbornMaleOximetryRandomized Controlled Trials as TopicSpectroscopy, Near-InfraredOxygenamplitude‐integrated electroencephalographyelectrocortical activityNIRSpreterm infanttotal maturation score

Identifiers

PMID40576369
PMCPMC12520279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.