The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection.
Audrey C Brown, Md Jashim Uddin, Rebecca M Munday, Farha Naz, G Brett Moreau, Girija Ramakrishnan, Stephen S Rich, Rashidul Haque, Genevieve L Wojcik, Priya Duggal and 2 more
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Audrey C BrownDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0001-5572-0396
Md Jashim UddinDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Rebecca M MundayDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Farha NazDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
G Brett MoreauDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0001-6032-4320
Girija RamakrishnanDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Stephen S RichDepartment of Genome Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Rashidul HaqueInternational Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Genevieve L WojcikDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Priya DuggalDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Chelsea MarieDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0001-8193-2771
William A PetriDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0002-7268-1218
Funding
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
STRUCTURE/FUNCTION OF E HISTOLYTICA ADHERENCE LECTINR01AI026649 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PETRI, WILLIAM A · 1989 to 2016
$6.1M
Role of CREM in Amebic Colitis and Inflammatory Bowel DiseaseR37AI026649 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2018 to 2026
$5.0M
Bill and Melinda Gates Foundation OPP1017093, OP1136759National Institute of Allergy and Infectious Diseases AI026649NIAID NIH HHS R01 AI026649NIAID NIH HHS R01 AI043596NIAID NIH HHS R37 AI026649NIAID NIH HHS T32 AI007496Pharmaceutical Research and Manufacturers of America Foundation Translational Medicine Postdoctoral FellowshipSchool of Medicine, University of Virginia 5T32AI007496
6 · The paper itself
Abstract
We previously identified genetic polymorphisms associated with
Indexed as
Cyclic AMP Response Element ModulatorDiarrheaGenetic Predisposition to DiseaseMalnutritionAnimalsBangladeshEntamoeba histolyticaFemaleHumansInfantIntestine, SmallMaleMicePolymorphism, Single NucleotideCREM protein, humanCyclic AMP Response Element Modulatoramebiasisgenetic susceptibilitymalnutritionmetabolomicstranscriptomicsundernutrition
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection. · full record | OpenQuestion